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Gene Review

PEX11  -  Pex11p

Saccharomyces cerevisiae S288c

Synonyms: O0454, PMP24, PMP27, Peroxin-11, Peroxisomal membrane protein PMP27, ...
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High impact information on PEX11

  • Proliferation of the organelle is regulated by Pex11p [1].
  • Overexpression of the genes PEX25 or VPS1, but not the gene PEX11, restored the wild-type phenotype to cells deleted for one or both of the YHR150w and YDR479c genes [2].
  • PEX11 promotes peroxisome division independently of peroxisome metabolism [3].
  • We report that mutants deficient in genes required for medium-chain fatty acid (MCFA) beta-oxidation display the same phenotype as Pex11p-deficient cells [4].
  • Particulate structures containing the peroxisomal integral membrane proteins Pex3p and Pex11p are evident in pex17 mutant cells, indicating the existence of peroxisomal remnants ("ghosts") [5].

Biological context of PEX11


Anatomical context of PEX11

  • Overexpression of YOR193w, PEX25, or PEX11 led to peroxisome proliferation and the formation of small peroxisomes [11].
  • Pex13p deficient cells retain membranes containing the peroxisomal membrane protein Pex11p (former Pmp27p), consistent with the existence of independent pathways for the integration of peroxisomal membrane proteins and for the translocation of peroxisomal matrix proteins [12].
  • Thus trypanosomes require both GIM5B and PEX11 for the maintenance of normal glycosome numbers [13].
  • The induced peroxisomes of delta pmp27 cells were fewer but considerably larger than those of wild-type cells, suggesting that Pmp27p may be involved in parceling of peroxisomes into regular quanta. delta pmp27 cells cultured in oleate-containing media form multiple buds, of which virtually all are peroxisome deficient [14].

Associations of PEX11 with chemical compounds

  • Unlike Pex25p and Pex11p, Yor193p is constitutively expressed in wild-type cells grown in oleic acid-containing medium, the metabolism of which requires intact peroxisomes [11].
  • When PEX11 mutant cells are shifted from glucose to oleate-containing medium, we observed an immediate deficiency in beta-oxidation of MCFAs whereas giant peroxisomes and a failure to increase peroxisome abundance only became apparent much later [4].
  • Pex11p (formerly Pmp27) has been implicated in peroxisomal proliferation (Erdmann, R., and G. Blobel. 1995. J. Cell Biol. 128; 509-523; Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Dyer, M. Veenhuis, and J.M. Goodman, 1995. J. Cell Biol. 129; 345-355) [15].
  • The authors' studies show that Pex11p is involved in peroxisome proliferation; Pmp47 plays a role in the translocation, folding, or assembly of dihydroxyacetone synthase; and Pmp20 is probably involved in methanol metabolism [16].

Other interactions of PEX11


  1. Peroxisome biogenesis. Purdue, P.E., Lazarow, P.B. Annu. Rev. Cell Dev. Biol. (2001) [Pubmed]
  2. YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae. Vizeacoumar, F.J., Torres-Guzman, J.C., Tam, Y.Y., Aitchison, J.D., Rachubinski, R.A. J. Cell Biol. (2003) [Pubmed]
  3. PEX11 promotes peroxisome division independently of peroxisome metabolism. Li, X., Gould, S.J. J. Cell Biol. (2002) [Pubmed]
  4. Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae. van Roermund, C.W., Tabak, H.F., van Den Berg, M., Wanders, R.J., Hettema, E.H. J. Cell Biol. (2000) [Pubmed]
  5. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. Huhse, B., Rehling, P., Albertini, M., Blank, L., Meller, K., Kunau, W.H. J. Cell Biol. (1998) [Pubmed]
  6. Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis. Rottensteiner, H., Stein, K., Sonnenhol, E., Erdmann, R. Mol. Biol. Cell (2003) [Pubmed]
  7. Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11. Gurvitz, A., Hiltunen, J.K., Erdmann, R., Hamilton, B., Hartig, A., Ruis, H., Rottensteiner, H. J. Biol. Chem. (2001) [Pubmed]
  8. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11. Abe, I., Okumoto, K., Tamura, S., Fujiki, Y. FEBS Lett. (1998) [Pubmed]
  9. Pmp27 promotes peroxisomal proliferation. Marshall, P.A., Krimkevich, Y.I., Lark, R.H., Dyer, J.M., Veenhuis, M., Goodman, J.M. J. Cell Biol. (1995) [Pubmed]
  10. Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals. Rottensteiner, H., Kramer, A., Lorenzen, S., Stein, K., Landgraf, C., Volkmer-Engert, R., Erdmann, R. Mol. Biol. Cell (2004) [Pubmed]
  11. Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae. Tam, Y.Y., Torres-Guzman, J.C., Vizeacoumar, F.J., Smith, J.J., Marelli, M., Aitchison, J.D., Rachubinski, R.A. Mol. Biol. Cell (2003) [Pubmed]
  12. Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. Erdmann, R., Blobel, G. J. Cell Biol. (1996) [Pubmed]
  13. Depletion of GIM5 causes cellular fragility, a decreased glycosome number, and reduced levels of ether-linked phospholipids in trypanosomes. Voncken, F., van Hellemond, J.J., Pfisterer, I., Maier, A., Hillmer, S., Clayton, C. J. Biol. Chem. (2003) [Pubmed]
  14. Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. Erdmann, R., Blobel, G. J. Cell Biol. (1995) [Pubmed]
  15. Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division. Marshall, P.A., Dyer, J.M., Quick, M.E., Goodman, J.M. J. Cell Biol. (1996) [Pubmed]
  16. Environmental response of yeast peroxisomes. Aspects of organelle assembly and degradation. Sakai, Y., Subramani, S. Cell Biochem. Biophys. (2000) [Pubmed]
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