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Gene Review

SNF6  -  Snf6p

Saccharomyces cerevisiae S288c

Synonyms: SWI/SNF complex component SNF6, Transcription regulatory protein SNF6, YHL025W
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High impact information on SNF6

  • Here, we present evidence that SNF6 has a more direct role in stimulating transcription than SNF2 and SNF5 [1].
  • Previously, we showed that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex [1].
  • The N terminus of SNF6 contains a sequence homologous to nuclear localization signals and was sufficient to direct beta-galactosidase to the nucleus [2].
  • The SNF6 coding sequence was identified by selective mutagenesis [2].
  • Null mutations in SNF6 caused a wider range of pleiotropic defects than the previously isolated point mutation, including slow growth [2].

Biological context of SNF6


Other interactions of SNF6

  • The ssn20 mutations also suppressed the defects in invertase derepression caused by snf5 and snf6 mutations, and selection for invertase-producing revertants of snf5 mutants yielded only additional ssn20 alleles [5].
  • The SNF2, SNF5 and SNF6 genes are required for Ty transcription in Saccharomyces cerevisiae [6].
  • Strains bearing a mutation in any of the SNF1-SNF6 genes cannot derepress secreted invertase synthesis, but did derepress PrB synthesis when grown in the absence of glucose [7].

Analytical, diagnostic and therapeutic context of SNF6

  • A bifunctional SNF6-beta-galactosidase fusion protein was localized in the nucleus, as judged by immunofluorescence microscopy [2].


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