High impact information on DUR3

• URP2 was assigned to the left arm of chromosome VIII, and maps between DUR3 and YLF1 [1].
• A defect in the yeast plasma membrane urea transporter Dur3p is complemented by CpNIP1, a Nod26-like protein from zucchini (Cucurbita pepo L.), and by Arabidopsis thaliana delta-TIP or gamma-TIP [2].
• In the mutant, the PUT4 mRNA encoding the proline permease is not affected, whereas the DUR3 mRNA, involved in urea active transport, is strongly increased [3].
• Maintenance of DUR3 mRNA at uninduced, nonrepressed basal levels requires the negatively acting DAL80 gene product [4].
• DUR3 expression is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product [4].

Biological context of DUR3

• The DUR3 gene, which encodes a component required for active transport of urea in Saccharomyces cerevisiae, has been isolated, and its sequence has been determined [4].

Anatomical context of DUR3

• Dur3 encodes the yeast plasma membrane urea transporter and Deltadur3 mutants are unable to grow on media containing low concentrations of urea as sole nitrogen source [2].

Associations of DUR3 with chemical compounds

• Expression of DUR3 is regulated in a manner similar to that of other genes in the allantoin pathway [4].

Other interactions of DUR3

• The boron concentration in yeast cells lacking BOR1 was elevated upon exposure to 90 mM boric acid, whereas cells lacking DUR3 or FPS1 showed lower boron concentrations [5].

References