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Gene Review

FPS1  -  Fps1p

Saccharomyces cerevisiae S288c

Synonyms: Glycerol uptake/efflux facilitator protein, YLL043W
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Disease relevance of FPS1


High impact information on FPS1

  • Two of these cell fusion mutants are defective in the FPS1 gene, which codes for a glycerol facilitator (Luyten, K., J. Albertyn, W.F. Skibbe, B.A. Prior, J. Ramos, J.M. Thevelein, and S. Hohmann. 1995. EMBO [Eur. Mol. Biol. Organ.] J. 14:1360-1371) [3].
  • The suppression of ggs1/tps1 delta mutants by GPD1 depends on the presence of Fps1 [4].
  • Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress [4].
  • Here we show that overexpression of FPS1 enhances glycerol production [4].
  • Glycerol-uptake experiments showed that the permeability of the yeast plasma membrane for glycerol consists of an Fps1-independent component probably due to simple diffusion and of an Fps1-dependent component representing facilitated diffusion [4].

Biological context of FPS1


Anatomical context of FPS1


Associations of FPS1 with chemical compounds


Regulatory relationships of FPS1


Other interactions of FPS1

  • We find that loss of function mutations in FPS1, a gene encoding the major glycerol transporter in yeast activates the reporter in a SLN1-dependent fashion [17].
  • The yeast hnRNP-like protein Hrp1/Nab4 sccumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response [5].
  • As in S. cerevisiae, chromosomal linkage between the K. lactis QCR8 and FPS1 genes is conserved, the two genes being separated by only 292 bp [12].
  • In agreement with this finding, hog1 cells containing an fps1 allele, encoding a constitutively open glycerol channel, have lost their temperature-remedial osmoresistance [18].
  • The roles of three membrane proteins, BOR1, DUR3, and FPS1, in boron (B) transport in yeast were examined [19].

Analytical, diagnostic and therapeutic context of FPS1


  1. The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Wysocki, R., Chéry, C.C., Wawrzycka, D., Van Hulle, M., Cornelis, R., Thevelein, J.M., Tamás, M.J. Mol. Microbiol. (2001) [Pubmed]
  2. Functional identification of the glycerol permease activity of Arabidopsis thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces cerevisiae. Weig, A.R., Jakob, C. FEBS Lett. (2000) [Pubmed]
  3. Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae. Philips, J., Herskowitz, I. J. Cell Biol. (1997) [Pubmed]
  4. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. Luyten, K., Albertyn, J., Skibbe, W.F., Prior, B.A., Ramos, J., Thevelein, J.M., Hohmann, S. EMBO J. (1995) [Pubmed]
  5. The yeast hnRNP-like protein Hrp1/Nab4 sccumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response. Henry, M.F., Mandel, D., Routson, V., Henry, P.A. Mol. Biol. Cell (2003) [Pubmed]
  6. Glycerol export and glycerol-3-phosphate dehydrogenase, but not glycerol phosphatase, are rate limiting for glycerol production in Saccharomyces cerevisiae. Remize, F., Barnavon, L., Dequin, S. Metab. Eng. (2001) [Pubmed]
  7. Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae. Sutherland, F.C., Lages, F., Lucas, C., Luyten, K., Albertyn, J., Hohmann, S., Prior, B.A., Kilian, S.G. J. Bacteriol. (1997) [Pubmed]
  8. Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling. Karlgren, S., Pettersson, N., Nordlander, B., Mathai, J.C., Brodsky, J.L., Zeidel, M.L., Bill, R.M., Hohmann, S. J. Biol. Chem. (2005) [Pubmed]
  9. An aquaglyceroporin is abundantly expressed early in the development of the suspensor and the embryo proper of loblolly pine. Ciavatta, V.T., Morillon, R., Pullman, G.S., Chrispeels, M.J., Cairney, J. Plant Physiol. (2001) [Pubmed]
  10. Water transport across yeast vacuolar and plasma membrane-targeted secretory vesicles occurs by passive diffusion. Coury, L.A., Hiller, M., Mathai, J.C., Jones, E.W., Zeidel, M.L., Brodsky, J.L. J. Bacteriol. (1999) [Pubmed]
  11. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. Liu, Z., Boles, E., Rosen, B.P. J. Biol. Chem. (2004) [Pubmed]
  12. Isolation and characterisation of the linked genes, FPS1 and QCR8, coding for farnesyl-diphosphate synthase and the 11 kDa subunit VIII of the mitochondrial bc1-complex in the yeast Kluyveromyces lactis. Mulder, W., Scholten, I.H., Nagelkerken, B., Grivell, L.A. Biochim. Biophys. Acta (1994) [Pubmed]
  13. Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces cerevisiae. Toh, T.H., Kayingo, G., van der Merwe, M.J., Kilian, S.G., Hallsworth, J.E., Hohmann, S., Prior, B.A. FEMS Yeast Res. (2001) [Pubmed]
  14. Fps1p channel is the mediator of the major part of glycerol passive diffusion in Saccharomyces cerevisiae: artefacts and re-definitions. Oliveira, R., Lages, F., Silva-Graça, M., Lucas, C. Biochim. Biophys. Acta (2003) [Pubmed]
  15. Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. Mollapour, M., Piper, P.W. Mol. Cell. Biol. (2007) [Pubmed]
  16. Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae. Kong, Q.X., Gu, J.G., Cao, L.M., Zhang, A.L., Chen, X., Zhao, X.M. Biotechnol. Lett. (2006) [Pubmed]
  17. Intracellular glycerol levels modulate the activity of Sln1p, a Saccharomyces cerevisiae two-component regulator. Tao, W., Deschenes, R.J., Fassler, J.S. J. Biol. Chem. (1999) [Pubmed]
  18. The control of intracellular glycerol in Saccharomyces cerevisiae influences osmotic stress response and resistance to increased temperature. Siderius, M., Van Wuytswinkel, O., Reijenga, K.A., Kelders, M., Mager, W.H. Mol. Microbiol. (2000) [Pubmed]
  19. Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae. Nozawa, A., Takano, J., Kobayashi, M., von Wirén, N., Fujiwara, T. FEMS Microbiol. Lett. (2006) [Pubmed]
  20. Analysis of the pore of the unusual major intrinsic protein channel, yeast Fps1p. Bill, R.M., Hedfalk, K., Karlgren, S., Mullins, J.G., Rydström, J., Hohmann, S. J. Biol. Chem. (2001) [Pubmed]
  21. Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes. Cunillera, N., Arró, M., Delourme, D., Karst, F., Boronat, A., Ferrer, A. J. Biol. Chem. (1996) [Pubmed]
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