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Gene Review

PDE8B  -  phosphodiesterase 8B

Homo sapiens

Synonyms: ADSD, Cell proliferation-inducing gene 22 protein, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, HsPDE8B, PIG22, ...
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Disease relevance of PDE8B

  • Expression of the thyroid-specific isobutyl-methyl-xanthine-insensitive phosphodiesterase 8B was absent in the normal pituitary but detectable in almost all GH-secreting adenomas and higher in gsp+ (P < 0.02) [1].

Psychiatry related information on PDE8B

  • When the expression of these isozymes in control brains was compared with that in Alzheimer's disease brains staged according to Braak and Braak (Acta Neuropathol. (Berl.) 82 (1991), 239), we found that PDE8B was the only isozyme showing a significant increase, in cortical areas and parts of the hippocampal formation, at Braak stages III-VI [2].

High impact information on PDE8B


Biological context of PDE8B

  • We have identified a novel human isozyme of 3',5'-cyclic nucleotide phosphodiesterase (PDE), which we designated PDE8B. cDNA of 2844 bp encoding the C-terminal 659 amino acids of PDE8B was cloned following the identification of an expressed sequence tag (EST) obtained through a search of the EST database [6].

Anatomical context of PDE8B

  • Northern blot analysis indicated that the mRNA encoding PDE8B is expressed specifically and abundantly in thyroid gland as a approximately 4.2 kb mRNA, in contrast to the wide expression of PDE8A mRNA in various tissues [6].

Other interactions of PDE8B

  • The predicted protein sequences of PDE8B showed highest homology (65% identity, 83% similarity) to that of PDE8A [6].

Analytical, diagnostic and therapeutic context of PDE8B

  • Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase [6].


  1. Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations. Persani, L., Borgato, S., Lania, A., Filopanti, M., Mantovani, G., Conti, M., Spada, A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  2. Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization. Pérez-Torres, S., Cortés, R., Tolnay, M., Probst, A., Palacios, J.M., Mengod, G. Exp. Neurol. (2003) [Pubmed]
  3. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi, T., Gamanuma, M., Sasaki, T., Yamashita, Y., Yuasa, K., Kotera, J., Omori, K. Gene (2003) [Pubmed]
  4. Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. Gamanuma, M., Yuasa, K., Sasaki, T., Sakurai, N., Kotera, J., Omori, K. Cell. Signal. (2003) [Pubmed]
  5. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Hayashi, M., Shimada, Y., Nishimura, Y., Hama, T., Tanaka, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. Hayashi, M., Matsushima, K., Ohashi, H., Tsunoda, H., Murase, S., Kawarada, Y., Tanaka, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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