The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PDE7B  -  phosphodiesterase 7B

Homo sapiens

Synonyms: cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PDE7B

  • Recombinant PDE7B protein expressed in a Baculovirus expression system is specific for cAMP with a K(m) of 0.03 microM [1].

High impact information on PDE7B


Biological context of PDE7B


Anatomical context of PDE7B


Associations of PDE7B with chemical compounds

  • The PDE7B activity was inhibited by dipyridamole and SCH51866, with IC(50) values of 1.1 microM and 1.5 microM, respectively [4].

Other interactions of PDE7B

  • The predicted protein sequence of PDE7B showed highest homology (70% identity) to that of PDE7A [3].

Analytical, diagnostic and therapeutic context of PDE7B


  1. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Hetman, J.M., Soderling, S.H., Glavas, N.A., Beavo, J.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization. Pérez-Torres, S., Cortés, R., Tolnay, M., Probst, A., Palacios, J.M., Mengod, G. Exp. Neurol. (2003) [Pubmed]
  3. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Gardner, C., Robas, N., Cawkill, D., Fidock, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Identification of human PDE7B, a cAMP-specific phosphodiesterase. Sasaki, T., Kotera, J., Yuasa, K., Omori, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
WikiGenes - Universities