The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VAMP4  -  vesicle-associated membrane protein 4

Homo sapiens

Synonyms: VAMP-4, VAMP24, Vesicle-associated membrane protein 4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on VAMP4


Biological context of VAMP4


Anatomical context of VAMP4

  • Both proteins had a distinct but overlapping localization. vtila was found predominantly on the Golgi and the TGN, vtilb mostly on tubules and vesicles in the TGN area and on endosomes. vti1a coimmunoprecipitated with VAMP-4, syntaxin 6, and syntaxin 16 [6].
  • VAMP4 is expressed in liver and skeletal muscle and participates in intracellular trafficking of secreted and membrane-associated proteins [7].

Associations of VAMP4 with chemical compounds

  • AP-1 association with VAMP4 is enhanced when serine 30, in an acidic cluster, is phosphorylated by casein kinase 2 [8].

Physical interactions of VAMP4


Co-localisations of VAMP4

  • In these compartments, VAMP4 was found to colocalize with the putative TGN-trafficking protein syntaxin 6 [4].

Other interactions of VAMP4

  • A dominant-negative PACS-1, which binds acidic clusters but not AP-1, also causes mislocalization of VAMP4 [8].
  • Replication in a separate sample, consisting of 190 triplets, confirmed the exploratory data for the SCN8A (P = 0.005) and VAMP4 (P = 0.019) genes, but failed to confirm the data for the RABAC1 gene [5].
  • Two SNAREs, VAMP4 and synaptotagmin IV, enter newly formed granules but are removed from the maturing granule membrane by vesicle budding [9].


  1. GGA function is required for maturation of neuroendocrine secretory granules. Kakhlon, O., Sakya, P., Larijani, B., Watson, R., Tooze, S.A. EMBO J. (2006) [Pubmed]
  2. Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Brandhorst, D., Zwilling, D., Rizzoli, S.O., Lippert, U., Lang, T., Jahn, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. Zeng, Q., Tran, T.T., Tan, H.X., Hong, W. J. Biol. Chem. (2003) [Pubmed]
  4. Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Steegmaier, M., Klumperman, J., Foletti, D.L., Yoo, J.S., Scheller, R.H. Mol. Biol. Cell (1999) [Pubmed]
  5. Suicide attempt and basic mechanisms in neural conduction: relationships to the SCN8A and VAMP4 genes. Wasserman, D., Geijer, T., Rozanov, V., Wasserman, J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  6. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Kreykenbohm, V., Wenzel, D., Antonin, W., Atlachkine, V., von Mollard, G.F. Eur. J. Cell Biol. (2002) [Pubmed]
  7. Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish. Sabra, M.M., Damcott, C., Fu, M., Ott, S., O'Connell, J.R., Mitchell, B.D., Shuldiner, A.R. Mol. Genet. Metab. (2005) [Pubmed]
  8. AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. Hinners, I., Wendler, F., Fei, H., Thomas, L., Thomas, G., Tooze, S.A. EMBO Rep. (2003) [Pubmed]
  9. Biosynthesis and secretion of pituitary hormones: dynamics and regulation. Moore, H.P., Andresen, J.M., Eaton, B.A., Grabe, M., Haugwitz, M., Wu, M.M., Machen, T.E. Arch. Physiol. Biochem. (2002) [Pubmed]
WikiGenes - Universities