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SYT4  -  synaptotagmin IV

Homo sapiens

Synonyms: HsT1192, KIAA1342, Synaptotagmin IV, Synaptotagmin-4, SytIV
 
 
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Disease relevance of SYT4

 

High impact information on SYT4

 

Biological context of SYT4

  • The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity [1].
  • The predicted amino acid sequence of the human SYT IV clone is nearly 90% identical to the rat and mouse SYT IV proteins [1].
  • However, both the frequency and the kinetics of NPY.Venus release were modulated by stimulus strength or by overexpression of synaptotagmin IV, demonstrating the plasticity of 'kiss-and-run' fusion [3].
 

Anatomical context of SYT4

 

Associations of SYT4 with chemical compounds

 

Other interactions of SYT4

  • Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets [5].
  • Blocking the activity of REST in A35C using a dominant-negative construct induced the reappearance of mRNAs for synaptophysin, chromogranin A, synaptotagmin IV and the beta3 subunit of the voltage-gated sodium channel (Scn3b), all of which contain RE1 sites in their genes [7].
  • Two SNAREs, VAMP4 and synaptotagmin IV, enter newly formed granules but are removed from the maturing granule membrane by vesicle budding [8].
  • Moreover, they are immunopositive for synaptotagmin IV, for AMPA receptor subunits GluR2,3 and, to a lesser extent, for GluR1 [9].

References

  1. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. Ferguson, G.D., Chen, X.N., Korenberg, J.R., Herschman, H.R. J. Biol. Chem. (2000) [Pubmed]
  2. Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. Ahras, M., Otto, G.P., Tooze, S.A. J. Cell Biol. (2006) [Pubmed]
  3. Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells. Tsuboi, T., Rutter, G.A. Biochem. Soc. Trans. (2003) [Pubmed]
  4. Variations of synaptotagmin I, synaptotagmin IV, and synaptophysin mRNA levels in rat hippocampus during the estrous cycle. Crispino, M., Stone, D.J., Wei, M., Anderson, C.P., Tocco, G., Finch, C.E., Baudry, M. Exp. Neurol. (1999) [Pubmed]
  5. Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets. Cunha, D.A., Amaral, M.E., Carvalho, C.P., Collares-Buzato, C.B., Carneiro, E.M., Boschero, A.C. Biol. Res. (2006) [Pubmed]
  6. Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Thomas, D.M., Ferguson, G.D., Herschman, H.R., Elferink, L.A. Mol. Biol. Cell (1999) [Pubmed]
  7. A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells. Pance, A., Livesey, F.J., Jackson, A.P. J. Neurochem. (2006) [Pubmed]
  8. Biosynthesis and secretion of pituitary hormones: dynamics and regulation. Moore, H.P., Andresen, J.M., Eaton, B.A., Grabe, M., Haugwitz, M., Wu, M.M., Machen, T.E. Arch. Physiol. Biochem. (2002) [Pubmed]
  9. Synaptobrevin2-expressing vesicles in rat astrocytes: insights into molecular characterization, dynamics and exocytosis. Crippa, D., Schenk, U., Francolini, M., Rosa, P., Verderio, C., Zonta, M., Pozzan, T., Matteoli, M., Carmignoto, G. J. Physiol. (Lond.) (2006) [Pubmed]
 
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