The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

STX6  -  syntaxin 6

Homo sapiens

Synonyms: Syntaxin-6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of STX6


High impact information on STX6


Biological context of STX6


Anatomical context of STX6


Associations of STX6 with chemical compounds


Physical interactions of STX6


Co-localisations of STX6

  • In these compartments, VAMP4 was found to colocalize with the putative TGN-trafficking protein syntaxin 6 [11].

Other interactions of STX6

  • The maturation block involves interference with the recruitment and function of rabs, rab effectors (phosphatidylinositol 3-kinases and tethering molecules such as EEA1), SNAREs (Syntaxin 6 and cellubrevin) and Ca2+/calmodulin signaling [13].
  • Syntaxin-4, but not syntaxin-6, was found to interact with SNAP-23 and was partially involved in mediator secretion from multiple compartments [7].
  • We demonstrate that fusion is largely mediated by a complex formed by syntaxin 13, syntaxin 6, vti1a, and VAMP4, whereas the exocytic and late endosomal SNAREs play little or no role in the reaction [14].
  • Syntaxin 16 knockdown with small interfering RNA (siRNA) affects the TGN localization of syntaxin 6 but not syntaxin 10, and clearly inhibits endosome-TGN transport [15].
  • On the other hand, knockdown of syntaxin 10 expressions had no significant effect on the TGN localization of syntaxin 6 and 16, and did not inhibit endosome-TGN transport [15].

Analytical, diagnostic and therapeutic context of STX6

  • This notion is confirmed using magnetic immunoisolation of PS1- or syntaxin 6-positive membrane patches from a mixture of membranes with similar buoyant densities following Lubrol WX extraction or sonication, and gradient centrifugation [16].


  1. Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface. Choudhury, A., Marks, D.L., Proctor, K.M., Gould, G.W., Pagano, R.E. Nat. Cell Biol. (2006) [Pubmed]
  2. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. Martín-Martín, B., Nabokina, S.M., Blasi, J., Lazo, P.A., Mollinedo, F. Blood (2000) [Pubmed]
  3. The Rab5 effector EEA1 interacts directly with syntaxin-6. Simonsen, A., Gaullier, J.M., D'Arrigo, A., Stenmark, H. J. Biol. Chem. (1999) [Pubmed]
  4. A new syntaxin family member implicated in targeting of intracellular transport vesicles. Bock, J.B., Lin, R.C., Scheller, R.H. J. Biol. Chem. (1996) [Pubmed]
  5. Regulation of Leukocyte Degranulation by cGMP-Dependent Protein Kinase and Phosphoinositide 3-Kinase: Potential Roles in Phosphorylation of Target Membrane SNARE Complex Proteins in Rat Mast Cells. Nanamori, M., Chen, J., Du, X., Ye, R.D. J. Immunol. (2007) [Pubmed]
  6. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. Charest, A., Lane, K., McMahon, K., Housman, D.E. J. Biol. Chem. (2001) [Pubmed]
  7. A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Logan, M.R., Lacy, P., Odemuyiwa, S.O., Steward, M., Davoine, F., Kita, H., Moqbel, R. Allergy (2006) [Pubmed]
  8. Control of vesicle fusion by a tyrosine phosphatase. Huynh, H., Bottini, N., Williams, S., Cherepanov, V., Musumeci, L., Saito, K., Bruckner, S., Vachon, E., Wang, X., Kruger, J., Chow, C.W., Pellecchia, M., Monosov, E., Greer, P.A., Trimble, W., Downey, G.P., Mustelin, T. Nat. Cell Biol. (2004) [Pubmed]
  9. Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network. Kessels, M.M., Dong, J., Leibig, W., Westermann, P., Qualmann, B. J. Cell. Sci. (2006) [Pubmed]
  10. Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. Zhang, Y., Shu, L., Chen, X. J. Biol. Chem. (2008) [Pubmed]
  11. Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Steegmaier, M., Klumperman, J., Foletti, D.L., Yoo, J.S., Scheller, R.H. Mol. Biol. Cell (1999) [Pubmed]
  12. Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. Ahras, M., Otto, G.P., Tooze, S.A. J. Cell Biol. (2006) [Pubmed]
  13. Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking. Vergne, I., Chua, J., Deretic, V. Traffic (2003) [Pubmed]
  14. Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Brandhorst, D., Zwilling, D., Rizzoli, S.O., Lippert, U., Lang, T., Jahn, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  15. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Wang, Y., Tai, G., Lu, L., Johannes, L., Hong, W., Luen Tang, B. Mol. Membr. Biol. (2005) [Pubmed]
  16. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. Vetrivel, K.S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P.C., Xu, H., Thinakaran, G. J. Biol. Chem. (2004) [Pubmed]
WikiGenes - Universities