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PACS1  -  phosphofurin acidic cluster sorting protein 1

Homo sapiens

Synonyms: FLJ10209, KIAA1175, PACS-1, Phosphofurin acidic cluster sorting protein 1
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Disease relevance of PACS1

  • These studies demonstrate the requirement for PACS-1 interactions with adaptor proteins in multiple processes, including secretory granule biogenesis and HIV-1 pathogenesis [1].
  • PACS-1 is a cytosolic protein involved in controlling the correct subcellular localization of integral membrane proteins that contain acidic cluster sorting motifs, such as furin and human immunodeficiency virus type 1 (HIV-1) NEF: We have now investigated the interaction of PACS-1 with heterotetrameric adaptor complexes [1].
  • Role of PACS-1 in trafficking of human cytomegalovirus glycoprotein B and virus production [2].
  • Severe ipsilateral carotid stenosis or occlusion was more common in PACS with cortical than lacunar infarcts (OR 3.5, 1.3-9.5); and in LACS with cortical than lacunar infarcts (OR 3.7, 1.1-12) [3].
  • Atrial fibrillation was more common in PACS with cortical than lacunar infarcts (OR 2.3, 95% confidence interval (95% CI) 0.9-5.5), and in LACS with cortical than lacunar infarcts (OR 3.9, 1.2-12) [3].

Psychiatry related information on PACS1

  • The PACS scales of defiance and hyperactivity, and similar subscales from Conners' Teacher Rating Scale, were tested against laboratory and clinical measures of activity, attention, cognitive performance, psychosocial background and family relationships [4].
  • Preliminary results from the first six months of the study suggest that the introduction of the RIS/PACS at the PAH has been well received by senior clinicians and has been helpful in clinical decision making [5].
  • Since the radiology department was using computed radiography (CR) and a picture archiving and communication system (PACS), research began to unearth the response times [6].
  • We take site visits very seriously, and have composed a package that includes information about the hospital, network/modality diagrams, EIT job descriptions, PACS information and various time studies that we have completed since going firmless [7].

High impact information on PACS1

  • These results support a model in which Nef relocalizes MHC-I by acting as a connector between MHC-I's cytoplasmic tail and the PACS-1-dependent protein-sorting pathway [8].
  • Despite executing opposing sorting steps, GGA3 and PACS-1 bind to an overlapping CI-MPR trafficking motif and their sorting activity is controlled by the CK2 phosphorylation of their respective autoregulatory domains [9].
  • A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking [9].
  • Cycling of CI-MPR between the TGN and early endosomes is mediated by GGA3, which directs TGN export, and PACS-1, which directs endosome-to-TGN retrieval [9].
  • The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic [10].

Chemical compound and disease context of PACS1


Biological context of PACS1

  • In-frame deletions in the first extracellular loop and C-terminal phosphofurin acidic cluster sorting protein-1 (PACS-1) binding sites in the cytoplasmic tail caused Polycystin-2 mislocalization to the apical cell surface [12].
  • A fundus PACS has been in clinical use since February 2000 at the ophthalmology clinic of Tampere University Hospital. It consists of a digital fundus camera, an imaging workstation, from which new patients can be added to the archive, 10 viewing stations and an image archive server [13].
  • CT, DSA, MRI, interventional radiology, ESWL, US, mammography, computers in radiology and PACS may save 10-80% of total cost for diagnosis and treatment of disease [14].
  • CONCLUSIONS: PACS exhibit down-regulation of CD44 protein expression, which correlates with high tumor grade and aneuploidy. v6 and v3 isoforms were preferentially expressed in the basal cells of benign prostatic acini [15].
  • It is usually recorded for a long period of time in the applications of telemedicine and PACS systems [16].

Anatomical context of PACS1

  • Expression of dominant-negative PACS-1 causes a mislocalization of both furin and mannose 6-phosphate receptor from the trans-Golgi network, but has no effect on the localization of proteins that do not contain acidic cluster sorting motifs [1].
  • CONCLUSION: CT scans obtained with multi-detector row scanners and interpreted with PACS workstations enable depiction of pancreas divisum [17].
  • However, Northern blot analysis with a fifth candidate gene, PACS1 (phosphofurin acidic cluster sorting protein), mapped to the deletion/FRA11A overlap region showed the expression of an 8-kb transcript in HeLa and five other tumor cell lines in addition to the expected 4.5-kb transcript [18].
  • Measurements of the depth and of the distance between the internal mammary vessels and the middle axis of the sternum were obtained using electronic calipers on a PACS workstation [19].
  • MATERIALS AND METHODS: For each of 44 patients who had a CT examination of the thorax, PA and lateral chest radiographs were produced using conventional film, hard copy CR and soft copy PACS images [20].

Associations of PACS1 with chemical compounds

  • It consists of a Digital Imaging and Communications in Medicine 3.0-based picture archiving and communication system (PACS), a diagnostic report server, and portable laptop computers [21].
  • A recent study in the West Surrey Health Authority demonstrated substantial advantages from viewing a picture archiving and communication system (PACS) as a whole-community asset, that is, a community PACS (CPACS) [22].
  • Both axial (2.5-mm section thickness) and coronal (1.3-2.0-mm section thickness) reformatted images were made and sent to picture archiving and communication system (PACS) monitors [23].
  • PACS workstation respecification: display, data flow, system integration, and environmental issues, derived from analysis of the Conquest Hospital pre-DICOM PACS experience [24].
  • As an introduction to Section C2 (medical imaging) of track C (Images and PACS) of MIE '97, an appropriate and timely topic concerns the coding for the transmission of medical images in PACS [25].

Physical interactions of PACS1

  • A short sequence within PACS-1 that is essential for binding to AP-1 has been identified [1].
  • AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 [26].

Other interactions of PACS1

  • A dominant-negative PACS-1, which binds acidic clusters but not AP-1, also causes mislocalization of VAMP4 [26].
  • We report a CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting [9].
  • Recently, however, novel vesicle coats (e.g. AP-4) and proteins that might be involved in sorting (e.g. PACS-1 and TIP47) have been described, and the interactions between assembly proteins and sorting signals are becoming increasingly well defined [27].
  • The analytical performances of the laboratory have been evaluated using three certified reference materials: the BCR 601 lake sediment for the BCR sequential extraction procedure, PACS-1 and MESS-1 for total metal concentration [28].

Analytical, diagnostic and therapeutic context of PACS1

  • PURPOSE: To determine the effect of a picture archiving and communication system (PACS) on reporting of incidental findings outside the area of interest, with a focus on lumbar spinal magnetic resonance (MR) imaging [29].
  • MATERIALS AND METHODS: The film-only system, which used either analog film or computed radiography (CR) hard copy, was compared with a PACS, which used CR images displayed on a multiviewer in the radiology department and a workstation in the medical intensive care unit [30].
  • Since 1991, an integrated radiotherapy network system has been developed, which consists of a picture archiving and communicating system (PACS), a radiotherapy information database, a CT simulator, and a linear accelerator with a multileaf collimator [31].
  • DESIGN: A prospective cohort study stratified for presence or absence of PACS [32].
  • As a result, the radiological physicist can expect to be confronted with elements of wavelet theory as diagnostic radiology advances into teleradiology, PACS, and computer aided feature extraction and diagnosis [33].


  1. PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. Crump, C.M., Xiang, Y., Thomas, L., Gu, F., Austin, C., Tooze, S.A., Thomas, G. EMBO J. (2001) [Pubmed]
  2. Role of PACS-1 in trafficking of human cytomegalovirus glycoprotein B and virus production. Crump, C.M., Hung, C.H., Thomas, L., Wan, L., Thomas, G. J. Virol. (2003) [Pubmed]
  3. Should computed tomography appearance of lacunar stroke influence patient management? Mead, G.E., Lewis, S.C., Wardlaw, J.M., Dennis, M.S., Warlow, C.P. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  4. Conduct disorder and hyperactivity: I. Separation of hyperactivity and antisocial conduct in British child psychiatric patients. Taylor, E., Schachar, R., Thorley, G., Wieselberg, M. The British journal of psychiatry : the journal of mental science. (1986) [Pubmed]
  5. Implementation of a radiology information system/picture archiving and communication system and an image transfer system at a large public teaching hospital--assessment of success of adoption by clinicians. Crowe, B., Sim, L. Journal of telemedicine and telecare. (2004) [Pubmed]
  6. Using STAT properly. Wesp, W. Radiology management. (2006) [Pubmed]
  7. PACS support: the radiology approach. Hasley, T. Radiology management. (2002) [Pubmed]
  8. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Piguet, V., Wan, L., Borel, C., Mangasarian, A., Demaurex, N., Thomas, G., Trono, D. Nat. Cell Biol. (2000) [Pubmed]
  9. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. Scott, G.K., Fei, H., Thomas, L., Medigeshi, G.R., Thomas, G. EMBO J. (2006) [Pubmed]
  10. The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. Scott, G.K., Gu, F., Crump, C.M., Thomas, L., Wan, L., Xiang, Y., Thomas, G. EMBO J. (2003) [Pubmed]
  11. Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial. Roch??, H., Fumoleau, P., Spielmann, M., Canon, J.L., Delozier, T., Serin, D., Symann, M., Kerbrat, P., Souli??, P., Eichler, F., Viens, P., Monnier, A., Vindevoghel, A., Campone, M., Goudier, M.J., Bonneterre, J., Ferrero, J.M., Martin, A.L., Gen??ve, J., Asselain, B. J. Clin. Oncol. (2006) [Pubmed]
  12. Polycystin-2 immunolocalization and function in zebrafish. Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., Drummond, I.A. J. Am. Soc. Nephrol. (2006) [Pubmed]
  13. Picture archiving and fundus imaging in a glaucoma clinic. Lamminen, H. Journal of telemedicine and telecare. (2003) [Pubmed]
  14. Cost/benefit of high technology in diagnostic radiology. Göthlin, J.H. European journal of radiology. (1987) [Pubmed]
  15. Decreased levels of CD44 protein and mRNA in prostate carcinoma. Correlation with tumor grade and ploidy. Kallakury, B.V., Yang, F., Figge, J., Smith, K.E., Kausik, S.J., Tacy, N.J., Fisher, H.A., Kaufman, R., Figge, H., Ross, J.S. Cancer (1996) [Pubmed]
  16. Data compression for arterial pulse waveform. Chen, W.S., Yuan, S.Y., Liao, H.E. Am. J. Chin. Med. (2001) [Pubmed]
  17. Pancreas divisum: depiction with multi-detector row CT. Soto, J.A., Lucey, B.C., Stuhlfaut, J.W. Radiology. (2005) [Pubmed]
  18. A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13. Zainabadi, K., Benyamini, P., Chakrabarti, R., Veena, M.S., Chandrasekharappa, S.C., Gatti, R.A., Srivatsan, E.S. Genomics (2005) [Pubmed]
  19. CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning. Kirova, Y.M., Servois, V., Campana, F., Dendale, R., Bollet, M.A., Laki, F., Fournier-Bidoz, N., Fourquet, A. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2006) [Pubmed]
  20. A comparison of conventional film, CR hard copy and PACS soft copy images of the chest: analyses of ROC curves and inter-observer agreement. Weatherburn, G.C., Ridout, D., Strickland, N.H., Robins, P., Glastonbury, C.M., Curati, W., Harvey, C., Shadbolt, C. European journal of radiology. (2003) [Pubmed]
  21. Wireless local area networking for linking a PC reporting system and PACS: clinical feasibility in emergency reporting. Yoshihiro, A., Nakata, N., Harada, J., Tada, S. Radiographics : a review publication of the Radiological Society of North America, Inc. (2002) [Pubmed]
  22. The north-west region community PACS study. Navein, J. Journal of telemedicine and telecare. (2002) [Pubmed]
  23. Additional coronal images using low-milliamperage multidetector-row computed tomography: effectiveness in the diagnosis of bronchiectasis. Sung, Y.M., Lee, K.S., Yi, C.A., Yoon, Y.C., Kim, T.S., Kim, S. Journal of computer assisted tomography. (2003) [Pubmed]
  24. PACS workstation respecification: display, data flow, system integration, and environmental issues, derived from analysis of the Conquest Hospital pre-DICOM PACS experience. Foord, K.D. European radiology. (1999) [Pubmed]
  25. A review of compression methods for medical images in PACS. Strintzis, M.G. International journal of medical informatics. (1998) [Pubmed]
  26. AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. Hinners, I., Wendler, F., Fei, H., Thomas, L., Thomas, G., Tooze, S.A. EMBO Rep. (2003) [Pubmed]
  27. Bi-directional trafficking between the trans-Golgi network and the endosomal/lysosomal system. Rohn, W.M., Rouillé, Y., Waguri, S., Hoflack, B. J. Cell. Sci. (2000) [Pubmed]
  28. Comparison of three sequential extraction procedures (original and modified 3 steps BCR procedure) applied to sediments of different origin. Craba, L., Brunori, C., Galletti, M., Cremisini, C., Morabito, R. Annali di chimica. (2004) [Pubmed]
  29. Picture archiving and communication system: effect on reporting of incidental findings. Wagner, S.C., Morrison, W.B., Carrino, J.A., Schweitzer, M.E., Nothnagel, H. Radiology. (2002) [Pubmed]
  30. Prospective study of a PACS: information flow and clinical action in a medical intensive care unit. Kundel, H.L., Seshadri, S.B., Langlotz, C.P., Lanken, P.N., Horii, S.C., Nodine, C.F., Polansky, M., Feingold, E., Brikman, I., Bozzo, M., Redfern, R. Radiology. (1996) [Pubmed]
  31. Development of an integrated radiotherapy network system. Nagata, Y., Okajima, K., Murata, R., Mitsumori, M., Mizowaki, T., Yamamoto, M., Hiraoka, M., Nishidai, T., Nakata, M., Abe, M., Sugahara, K., Arimura, H., Hosoba, M., Morisawa, H., Kazusa, C., Ai, D., Kokubo, M. Int. J. Radiat. Oncol. Biol. Phys. (1996) [Pubmed]
  32. A picture archival and communication system shortens delays in obtaining radiographic information in a medical intensive care unit. Redfern, R.O., Kundel, H.L., Polansky, M., Langlotz, C.P., Horii, S.C., Lanken, P.N. Crit. Care Med. (2000) [Pubmed]
  33. An introduction to wavelet theory and application for the radiological physicist. Harpen, M.D. Medical physics. (1998) [Pubmed]
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