Disease relevance of EDG6

• In addition, SPP activated extracellular signal-regulated kinase (Erk) in EDG-6 transfected cells in a pertussis toxin-sensitive manner [1].

High impact information on EDG6

• LPA did not compete for binding of SPP at any concentration tested, whereas sphingosylphosphorylcholine competed for binding to EDG-6, but only at very high concentrations [1].
• EDG-6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family that is expressed in lymphoid and hematopoietic tissue and in the lung [1].
• We show that mir-9 acts by diminishing the expression of the transcription factor Onecut-2 and, in turn, by increasing the level of Granuphilin/Slp4, a Rab GTPase effector associated with beta-cell secretory granules that exerts a negative control on insulin release [2].
• In treated immature and mature DC, expression levels for two S1PR proteins, S1P1 and S1P4, were reduced [3].
• Because of the known mitogenic and chemotactic activity of bioactive lipids, we believe that EDG6 may play an essential role in lymphocyte cell signaling [4].

Biological context of EDG6

• The human edg6 gene was mapped to chromosome 19p13.3 at the D19S120 marker [4].

Anatomical context of EDG6

• Here we report the identification and characterization of EDG6, a novel member of the EDG receptor family, isolated from in vitro differentiated human and murine dendritic cells [4].

Associations of EDG6 with chemical compounds

• RESULTS: We tested whether mutation of this "ligand selectivity" residue to glutamine could confer LPA-responsiveness to the related S1P receptor, S1P4 [5].
• Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists [6].
• We find that diaziquone free radicals are more stable than RQ14 but less stable than RQ2 free radicals [7].

Other interactions of EDG6

• S1P1 expression was weak, and no significant expression of either S1P4 or S1P5 was detected [8].

References