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Gene Review

S1PR5  -  sphingosine-1-phosphate receptor 5

Homo sapiens

Synonyms: EDG8, Edg-8, Endothelial differentiation G-protein-coupled receptor 8, S1P receptor 5, S1P receptor Edg-8, ...
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Disease relevance of EDG8


High impact information on EDG8


Biological context of EDG8


Anatomical context of EDG8

  • 1 (Edg 1), 2 (Edg 5), 3 (Edg 3), 4 (Edg 6), and 5 (Edg 8) mRNA in keratinocytes was identified [6].
  • These Edg-8-positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels [5].
  • After 32 weeks of gestation, radial glial fibers gradually disappear; instead Edg-8-positive transitional stages between radial glia and astrocytes were found [5].
  • In conclusion, PLD is one of the signalling components linking SPP-receptor activation to assembly of actin stress fibres [7].

Associations of EDG8 with chemical compounds

  • In Chinese hamster ovary cells heterologously expressing EDG-8, S1P inhibited forskolin-induced cAMP accumulation and activated c-Jun NH2-terminal kinase [2].

Other interactions of EDG8


  1. Localization and expression of cornifin-alpha/SPRR1 in mouse epidermis, anagen hair follicles, and skin neoplasms. Owens, D.M., Zainal, T.A., Jetten, A.M., Smart, R.C. J. Invest. Dermatol. (1996) [Pubmed]
  2. Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. Malek, R.L., Toman, R.E., Edsall, L.C., Wong, S., Chiu, J., Letterle, C.A., Van Brocklyn, J.R., Milstien, S., Spiegel, S., Lee, N.H. J. Biol. Chem. (2001) [Pubmed]
  3. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Hla, T., Lee, M.J., Ancellin, N., Thangada, S., Liu, C.H., Kluk, M., Chae, S.S., Wu, M.T. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  4. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. Wang, F., Van Brocklyn, J.R., Hobson, J.P., Movafagh, S., Zukowska-Grojec, Z., Milstien, S., Spiegel, S. J. Biol. Chem. (1999) [Pubmed]
  5. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. Ulfig, N., Briese, M. Acta Histochem. (2004) [Pubmed]
  6. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. Vogler, R., Sauer, B., Kim, D.S., Schäfer-Korting, M., Kleuser, B. J. Invest. Dermatol. (2003) [Pubmed]
  7. Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. Porcelli, A.M., Ghelli, A., Hrelia, S., Rugolo, M. Cell. Signal. (2002) [Pubmed]
  8. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. Yamashita, H., Kitayama, J., Shida, D., Yamaguchi, H., Mori, K., Osada, M., Aoki, S., Yatomi, Y., Takuwa, Y., Nagawa, H. J. Surg. Res. (2006) [Pubmed]
  9. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. Kothapalli, R., Kusmartseva, I., Loughran, T.P. Biochim. Biophys. Acta (2002) [Pubmed]
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