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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CCA1  -  cataract, congenital, cerulean type, 1

Homo sapiens

Synonyms: CTRCT7
 
 
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Disease relevance of CCA1

  • We have generated a monoclonal antibody (MAb), FS01, which inhibits the procoagulant activity (CCA-1) produced by a human squamous cell carcinoma cell line, LK52 [1].
  • Association between Ley expression and prognosis of breast cancer was investigated using monoclonal antibody (MoAb) FS01, which recognizes Ley as an epitope, inhibits the procoagulant activity of cancer cell-derived coagulating activity 1 (CCA-1) [2].
  • These findings indicate that Ley glycolipid plays an important role in the mechanism of cancer metastasis via the procoagulant activity of CCA-1 [3].
  • Monoclonal antibody (MoAb) FS01, which serves as the Ley-recognizing epitope, inhibits the procoagulant activity of CCA-1 was found to dose-dependently inhibit the procoagulant activity of normal plasma induced by the human lung adenocarcinoma cell line, HAL8, which shows a high level of Ley expression [3].
 

High impact information on CCA1

  • CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis [4].
  • The similar circadian phenotypes of lines overexpressing either CCA1 or LHY have suggested that the functions of these two transcription factors are largely overlapping. cca1-1 plants, which lack CCA1 protein, show a short-period phenotype for the expression of several genes when assayed under constant light conditions [5].
  • Six C. capucinus chromosomes are homologous to parts of two human chromosomes: CCA 1 = HSA 5 + 7 part; CCA 4 = HSA 2p + q proximal + 16q; CCA 5 = HSA 10q + 16p; CCA 6 = HSA 14 + 15 part; CCA 7 = HSA 8p + 18; and CCA 9 = HSA 3 part + 21 [6].
  • CCA-1 and tissue factor plays a important role in the blood coagulating activity of breast cancer cell lines [2].
  • Breast cancer patients are thought to have a poor prognosis because Ley expression on the surface of the cancer cell induces blood coagulation via CCA-1 [2].
 

Analytical, diagnostic and therapeutic context of CCA1

References

  1. Le(y) glycolipid acts as a co-factor for tumor procoagulant activity. Suzuki, M., Inufusa, H., Yamamoto, S., Hamada, T., Aga, M., Ando, O., Ohta, T., Yasutomi, M., Kurimoto, M. Int. J. Cancer (1997) [Pubmed]
  2. Correlation of prognosis of breast cancer patients and expression of Ley which acts as a cofactor of tumor procoagulant. Inufusa, H., Nakatani, Y., Adachi, T., Wakano, T., Nakajima, A., Nakamura, M., Suzuki, M., Ando, O., Kurimoto, M., Miyake, M., Shindo, K., Yasutomi, M. Int. J. Oncol. (1998) [Pubmed]
  3. Ley glycolipid-recognizing monoclonal antibody inhibits procoagulant activity and metastasis of human adenocarcinoma. Inufusa, H., Adachi, T., Kiyokawa, T., Nakatani, Y., Wakano, T., Nakamura, M., Okuno, K., Shiozaki, H., Yamamoto, S., Suzuki, M., Ando, O., Kurimoto, M., Miyake, M., Yasutomi, M. Int. J. Oncol. (2001) [Pubmed]
  4. CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis. Daniel, X., Sugano, S., Tobin, E.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Alabadí, D., Yanovsky, M.J., Más, P., Harmer, S.L., Kay, S.A. Curr. Biol. (2002) [Pubmed]
  6. ZOO-FISH suggests a complete homology between human and capuchin monkey (Platyrrhini) euchromatin. Richard, F., Lombard, M., Dutrillaux, B. Genomics (1996) [Pubmed]
  7. Generation of a monoclonal antibody that inhibits the procoagulant activity of various cancer cell lines. Inufusa, H., Adachi, T., Suzuki, M., Ando, O., Ohta, T., Kurimoto, M., Nakatani, Y., Nakamura, M., Yasutomi, M. Cancer (1998) [Pubmed]
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