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Gene Review

KCNK17  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: 2P domain potassium channel Talk-2, Acid-sensitive potassium channel protein TASK-4, K2p17.1, Potassium channel subfamily K member 17, TALK-2, ...
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High impact information on KCNK17

  • A lysine residue in TALK-2 fulfills the same role but with a largely unchanged pK(a), which correlates with an environment that stabilizes its positive charge [1].
  • Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species [2].
  • TASK-4 transcripts are widely expressed in humans, with highest levels in liver, lung, pancreas, placenta, aorta and heart [3].
  • Thus, TASK-4 in concert with other TASK channels might regulate cellular membrane potential over a wide range of extracellular pH [3].
  • TASK-4 currents were efficiently blocked by barium (83% inhibition at 2 mM), only weakly inhibited by 1 mM concentrations of quinine, bupivacaine and lidocaine, but not blocked by tetraethylammonium, 4-aminopyridine and Cs(+) [3].

Biological context of KCNK17

  • However, ear differences obtained in Task 1 did correlate significantly with certain visual field differences obtained in Task 4, suggesting that both tasks are sensitive to hemispheric asymmetry in similar phonetic or language-related processes [4].

Anatomical context of KCNK17

  • TALK-2 is mainly expressed in the pancreas, but is also expressed at a lower level in liver, placenta, heart, and lung [5].
  • In Xenopus oocytes TASK-4 generated K(+) currents displaying a marked outward rectification which was lost by elevation of extracellular K(+) [3].

Other interactions of KCNK17


Analytical, diagnostic and therapeutic context of KCNK17


  1. Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel. Niemeyer, M.I., Gonz??lez-Nilo, F.D., Z????iga, L., Gonz??lez, W., Cid, L.P., Sep??lveda, F.V. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. Duprat, F., Girard, C., Jarretou, G., Lazdunski, M. J. Physiol. (Lond.) (2005) [Pubmed]
  3. Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family. Decher, N., Maier, M., Dittrich, W., Gassenhuber, J., Brüggemann, A., Busch, A.E., Steinmeyer, K. FEBS Lett. (2001) [Pubmed]
  4. Individual variation in hemispheric asymmetry: multitask study of effects related to handedness and sex. Hellige, J.B., Bloch, M.I., Cowin, E.L., Eng, T.L., Eviatar, Z., Sergent, V. Journal of experimental psychology. General. (1994) [Pubmed]
  5. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Girard, C., Duprat, F., Terrenoire, C., Tinel, N., Fosset, M., Romey, G., Lazdunski, M., Lesage, F. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. TASK-5, a new member of the tandem-pore K(+) channel family. Kim, D., Gnatenco, C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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