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Gene Review

TAF1A  -  TATA box binding protein (TBP)-associated...

Homo sapiens

Synonyms: MGC:17061, RAFI48, RNA polymerase I-specific TBP-associated factor 48 kDa, SL1, TAFI48, ...
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Disease relevance of TAF1A

  • The role of the SL1 stem in heterozygous virion formation was also tested; our results indicated that the intermolecular base pairing of the stem sequences does not affect RNA partner selection [1].
  • Furthermore, promyelocytic leukemia protein, RNA polymerase II (Pol II), and the Pol I-associated transcription factor SL1 could be precipitated together with hepatitis delta antigen, suggesting the association of HDV replication complex with the Pol I and Pol II transcription machineries [2].

High impact information on TAF1A

  • Column chromatography and glycerol gradient sedimentation indicate that a subpopulation of TBP copurifies with SL1 activity [3].
  • TAFI48 also alters the ability of TBP to interact with TATA box elements, and the resulting complex fails to support transcription by RNA polymerase II [4].
  • Thus, TAFI48 may function both as a target to mediate UBF activation and as a class-specific promoter selectivity factor [4].
  • In mammalian RNA polymerase I transcription, SL1, an assembly of TBP and associated factors (TAFs), is essential for preinitiation complex formation at ribosomal RNA gene promoters in vitro [5].
  • In the transcription of human rRNA genes by RNA Polymerase I (Pol I), transcription factor SL1 has a role as the essential core promoter binding factor [6].

Biological context of TAF1A


Other interactions of TAF1A

  • We have determined that the human genes TAF1A, TAF1B and TAF1C, encoding these three TAF(I) polypeptides, are localized at lq42, 2p25 and 16q24, respectively [12].
  • We also demonstrate by an in vitro protein-protein interaction assay that TBP directly interacts with the smallest TAF, TAFI48 [7].


  1. Dimer Initiation Signal of Human Immunodeficiency Virus Type 1: Its Role in Partner Selection during RNA Copackaging and Its Effects on Recombination. Moore, M.D., Fu, W., Nikolaitchik, O., Chen, J., Ptak, R.G., Hu, W.S. J. Virol. (2007) [Pubmed]
  2. RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies. Li, Y.J., Macnaughton, T., Gao, L., Lai, M.M. J. Virol. (2006) [Pubmed]
  3. The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Comai, L., Tanese, N., Tjian, R. Cell (1992) [Pubmed]
  4. Coactivator and promoter-selective properties of RNA polymerase I TAFs. Beckmann, H., Chen, J.L., O'Brien, T., Tjian, R. Science (1995) [Pubmed]
  5. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. Gorski, J.J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J., Zomerdijk, J.C. EMBO J. (2007) [Pubmed]
  6. hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. Miller, G., Panov, K.I., Friedrich, J.K., Trinkle-Mulcahy, L., Lamond, A.I., Zomerdijk, J.C. EMBO J. (2001) [Pubmed]
  7. The conserved core domain of the human TATA binding protein is sufficient to assemble the multisubunit RNA polymerase I-specific transcription factor SL1. Rudloff, U., Eberhard, D., Grummt, I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. Bergstralh, D.T., Conti, B.J., Moore, C.B., Brickey, W.J., Taxman, D.J., Ting, J.P. Exp. Cell Res. (2007) [Pubmed]
  9. Regulation of RNA polymerase I transcription in response to F9 embryonal carcinoma stem cell differentiation. Alzuherri, H.M., White, R.J. J. Biol. Chem. (1999) [Pubmed]
  10. Physical mapping at 6q27 of the locus for the TATA box-binding protein, the DNA-binding subunit of TFIID and a component of SL1 and TFIIIB, strongly suggests that it is single copy in the human genome. Purrello, M., Di Pietro, C., Mirabile, E., Rapisarda, A., Rimini, R., Tinè, A., Pavone, L., Motta, S., Grzeschik, K.H., Sichel, G. Genomics (1994) [Pubmed]
  11. Sulfate metabolism in mycobacteria. Schelle, M.W., Bertozzi, C.R. Chembiochem (2006) [Pubmed]
  12. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. Di Pietro, C., Rapisarda, A., Amico, V., Bonaiuto, C., Viola, A., Scalia, M., Motta, S., Amato, A., Engel, H., Messina, A., Sichel, G., Grzeschik, K., Purrello, M. Cytogenet. Cell Genet. (2000) [Pubmed]
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