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Gene Review:

PIAS2 - protein inhibitor of activated STAT, 2

Homo sapiens

Synonyms: ARIP3, Androgen receptor-interacting protein 3, DAB2-interacting protein, DIP, E3 SUMO-protein ligase PIAS2, ...

van den Akker, E. et al., Zheng, Y. et al., Patel, J.H. et al., Takahashi, K. et al., Song, J. et al., et al.

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High impact information on PIAS2

These observations suggest that repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction [1].
Both PIASxalpha/ARIP3 and the closely related PIASxbeta isoform specifically enhanced sumoylation of FLI-1 at Lys(67), located in its N-terminal activation domain [2].
To understand the mechanism of SUMO recognition by the SBM, we have solved the solution structure of SUMO-1 in complex with a peptide containing the SBM derived from the protein PIASX (KVDVIDLTIESSSDEEEDPPAKR) [3].
PIASxalpha/ARIP3 relocalized the normally nuclear but diffusely distributed FLI-1 protein to PIASxalpha nuclear bodies and repressed FLI-1 transcriptional activation as assessed using different ETS-binding site-dependent promoters and different cell systems [2].
PIASx alpha inhibited the AR transcription activity in a dose-dependent manner in cotransfected monkey CV1 cells with an androgen responsive element-luciferase reporter [4].

Biological context of PIAS2

SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by the sumoylation of topoisomerase II [5].
CONCLUSION: PIAS-NY may play important role in testis development and/or spermatogenesis [6].
Tissue distribution analysis revealed that PIAS-NY was predominantly expressed in testis, weakly in the pancreas, and almost imperceptibly in the other organs [6].
RESULT: A new isoform of PIAS family, named PIAS-NY, was isolated from human testis cDNA library [6].
We recently demonstrated that apoptosis induction in primary human cells strictly requires that c-MYC bind and inactivate the transcription factor MIZ-1 [1].

Physical interactions of PIAS2

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor [4].

Other interactions of PIAS2

This interaction involved the ETS domain of FLI-1 and required the integrity of the SAP domain of PIASxalpha/ARIP3 [2].

Analytical, diagnostic and therapeutic context of PIAS2

Expression of PIAS-NY gene was analyzed by RT-PCR [6].

References

BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis. Patel, J.H., McMahon, S.B. J. Biol. Chem. (2007) [Pubmed]
FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family. van den Akker, E., Ano, S., Shih, H.M., Wang, L.C., Pironin, M., Palvimo, J.J., Kotaja, N., Kirsh, O., Dejean, A., Ghysdael, J. J. Biol. Chem. (2005) [Pubmed]
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. Song, J., Zhang, Z., Hu, W., Chen, Y. J. Biol. Chem. (2005) [Pubmed]
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2001) [Pubmed]
SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by the sumoylation of topoisomerase II. Takahashi, Y., Yong-Gonzalez, V., Kikuchi, Y., Strunnikov, A. Genetics (2006) [Pubmed]
Molecular cloning and characterization of a novel splicing variant of PIASx. Zheng, Y., Zhou, Z.M., Yin, L.L., Li, J.M., Sha, J.H. Acta Pharmacol. Sin. (2004) [Pubmed]

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