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Gene Review

NOMO1  -  NODAL modulator 1

Homo sapiens

Synonyms: Nodal modulator 1, Nomo, PM5, pM5 protein
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Disease relevance of NOMO1

  • In a comprehensive mutational screening, we have analysed the entire coding region of the pM5, MRP1, and NPIP genes in 7 patients affected with pseudoxanthoma elasticum, but failed to find evidence of disease-causing defects in any of these three genes [1].
  • PURPOSE: To quantify the proportion of heart volumes that received at least 25 Gy with tangential photon fields in patients with left-sided stage I (T1 NOMO) breast cancer treated with breast-conserving surgery [2].
  • On the other hand, PM5 showed stronger antibacterial activity than MSI-78, but being still accompanied with hemolysis at the MIC value [3].

High impact information on NOMO1

  • Accordingly, downregulation of Nomo resulted in an increase in anterior axial mesendoderm and the development of an enlarged hatching gland [4].
  • An increase in tissue factor (TF) was also demonstrated on the cell surface of NOMO-1 cells exposed to fragment D or D-dimer by indirect immunofluorescence using an anti-TF monoclonal antibody [5].
  • We studied the effect of fibrinogen degradation products D, E, and D-dimer on a human promonocytic leukemia cell line, NOMO-1 [5].
  • Four sequences were down-regulated in LNCaP-r cells, including an inactive variant of the E2 ubiquitin conjugating enzyme (UEV-1), a novel metalloproteinase-related collagenase (PM5), and a potential tumor suppressor gene (breast basic conserved gene, BBC1) [6].
  • RESULTS: NOMO-1 cells were found to express receptors for G-CSF [7].

Biological context of NOMO1

  • MTT and apoptosis assays revealed that K562/ADR, NOMO-1/ADR and NB4/RA/MDR were more sensitive to lovastatin than their parental cell lines, while NB4/MDR showed the same level of sensitivity as parental NB4 cells, which already were very sensitive to lovastatin [8].

Anatomical context of NOMO1

  • Although some exceptions exist, a similar tendency as to the effects of G-CSF treatment on cytokine secretions as that in NOMO-1 cells was observed in human monocytes [7].

Associations of NOMO1 with chemical compounds


Other interactions of NOMO1


Analytical, diagnostic and therapeutic context of NOMO1

  • Among the 27 patients staged T2-3 NOMO, 6 (CR, 1; PR, 5) underwent total cystectomies and 18 (CR, 8; PR, 8; NC, 2) had transurethral resection of a bladder tumor (TUR-Bt) or partial resections following chemotherapy [14].
  • Three Schiff bases of racemic gossypol with polyoxaalkylamines were synthesized and studied by FTIR and (1)H-NMR spectroscopy, and their structures were calculated by the PM5 semiempirical method [10].
  • This process of complex formation was studied by electrospray ionization-mass spectrometry, (1)H-NMR and Fourier transform infrared spectroscopy as well as by the PM5 semiempirical method [11].
  • A longer follow-up is necessary to evaluate the impact of the neoadjuvant chemotherapy on survival of category T3b-T4a (NOMO) bladder cancer [15].


  1. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. Perdu, J., Germain, D.P. Hum. Mutat. (2001) [Pubmed]
  2. Evaluation of irradiated heart volumes in stage I breast cancer patients treated with postoperative adjuvant radiotherapy. Gyenes, G., Gagliardi, G., Lax, I., Fornander, T., Rutqvist, L.E. J. Clin. Oncol. (1997) [Pubmed]
  3. Biological activities of 1,1,6-trisubstituted indanes: beyond magainin 2. Numao, N., Hirota, Y., Iwahori, A., Kidokoro, S., Sasatsu, M., Kondo, I., Itoh, S., Itoh, E., Katoh, T., Shimozono, N., Yamazaki, A., Takao, K., Kobayashi, S. Biol. Pharm. Bull. (1999) [Pubmed]
  4. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. Haffner, C., Frauli, M., Topp, S., Irmler, M., Hofmann, K., Regula, J.T., Bally-Cuif, L., Haass, C. EMBO J. (2004) [Pubmed]
  5. FDP D-dimer induces the secretion of interleukin-1, urokinase-type plasminogen activator, and plasminogen activator inhibitor-2 in a human promonocytic leukemia cell line. Hamaguchi, M., Morishita, Y., Takahashi, I., Ogura, M., Takamatsu, J., Saito, H. Blood (1991) [Pubmed]
  6. Differentially expressed genes in hormone refractory prostate cancer: association with chromosomal regions involved with genetic aberrations. Stubbs, A.P., Abel, P.D., Golding, M., Bhangal, G., Wang, Q., Waxman, J., Stamp, G.W., Lalani, E.N. Am. J. Pathol. (1999) [Pubmed]
  7. Granulocyte colony-stimulating factor directly affects human monocytes and modulates cytokine secretion. Saito, M., Kiyokawa, N., Taguchi, T., Suzuki, K., Sekino, T., Mimori, K., Suzuki, T., Nakajima, H., Katagiri, Y.U., Fujimura, J., Fujita, H., Ishimoto, K., Yamashiro, Y., Fujimoto, J. Exp. Hematol. (2002) [Pubmed]
  8. Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin. Maksumova, L., Ohnishi, K., Muratkhodjaev, F., Zhang, W., Pan, L., Takeshita, A., Ohno, R. Leukemia (2000) [Pubmed]
  9. Efficient deuterium-carbon REDOR NMR spectroscopy. Sack, I., Vega, S. J. Magn. Reson. (2000) [Pubmed]
  10. Spectroscopic studies and PM5 semiempirical calculations of new Schiff bases of gossypol with polyoxaalkylamines. Przybylski, P., Bartl, F., Brzezinski, B. Biopolymers (2002) [Pubmed]
  11. The schiff base of gossypol with 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine complexes and monovalent cations studied by electrospray ionization-mass spectrometry, (1)H nuclear magnetic resonance, Fourier transform infrared, as well as PM5 semiempirical methods. Przybylski, P., Brzezinski, B., Bartl, F. Biopolymers (2004) [Pubmed]
  12. Spectroscopic, mass spectrometry, and semiempirical investigation of a new ester of Monensin A with ethylene glycol and its complexes with monovalent metal cations. Huczyński, A., Przybylski, P., Brzezinski, B., Bartl, F. Biopolymers (2006) [Pubmed]
  13. Expression of HOX genes in acute leukemia cell lines with and without MLL translocations. Quentmeier, H., Dirks, W.G., Macleod, R.A., Reinhardt, J., Zaborski, M., Drexler, H.G. Leuk. Lymphoma (2004) [Pubmed]
  14. Phase II study of a new combined primary chemotherapy regimen, intravenous methotrexate and vincristine and intraarterial adriamycin and cisplatin, for locally advanced urinary bladder cancer: preliminary results. Kuroiwa, T., Naito, S., Hasuo, K., Kishikawa, T., Masuda, K., Kumazawa, J. Cancer Chemother. Pharmacol. (1995) [Pubmed]
  15. Neoadjuvant medium-dose methotrexate, cisplatin in category T3b-T4a (N0M0) bladder cancer. Pizzocaro, G., Pisani, E., Dormia, E., Piva, L., Maggioni, A., Minervini, G. Prog. Clin. Biol. Res. (1990) [Pubmed]
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