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Efna1  -  ephrin A1

Rattus norvegicus

Synonyms: EPH-related receptor tyrosine kinase ligand 1, Epgl1, Ephrin-A1, Immediate early response protein B61, LERK-1, ...
 
 
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High impact information on Efna1

  • In general, the studied Eph A were expressed on thymic epithelial cells, whereas ephrins A seem to be more restricted to thymocytes, although Eph A1 and ephrin A1 are expressed on both cell types [1].
  • Our results suggest that EphA receptors and ephrin-A ligands modify neuronal plasticity and may serve as spatial cues that modulate the development and pattern of activation-dependent axonal growth in adult CNS [2].
  • Prominent expression of EphA4, EphA7, and ephrin-A ligands was detected in muscle during embryonic development [3].
  • Unexpectedly, both ephrin A and B complexes increased process outgrowth: Seventy to eighty percent of neuronal precursors exhibited long neurites on ephrins, whereas only 5-10% of cells had neurites on IgG control substrates, indicating that ephrins stimulated neuritogenesis by early cortical neurons [4].
  • To search for gene expression changes probably responsible for deafferentation-induced reorganization in the brain, we have analyzed the expression of mRNAs for ephrin-A1, -A2, -A3, -A5 and -B1 in the rat hippocampus following transection of the entorhinal afferents by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) [5].
 

Regulatory relationships of Efna1

  • EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system [6].

References

  1. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus. Muñoz, J.J., Alonso-C, L.M., Sacedón, R., Crompton, T., Vicente, A., Jiménez, E., Varas, A., Zapata, A.G. J. Immunol. (2002) [Pubmed]
  2. EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats. Xu, B., Li, S., Brown, A., Gerlai, R., Fahnestock, M., Racine, R.J. Mol. Cell. Neurosci. (2003) [Pubmed]
  3. Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction. Lai, K.O., Ip, F.C., Cheung, J., Fu, A.K., Ip, N.Y. Mol. Cell. Neurosci. (2001) [Pubmed]
  4. Ephrins stimulate neurite outgrowth during early cortical neurogenesis. Zhou, X., Suh, J., Cerretti, D.P., Zhou, R., DiCicco-Bloom, E. J. Neurosci. Res. (2001) [Pubmed]
  5. Semi-quantitative expression analysis of ephrin mRNAs in the deafferented hippocampus. Wang, Y., Ying, G., Liu, X., Zhou, C. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  6. EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. St John, J.A., Pasquale, E.B., Key, B. Brain Res. Dev. Brain Res. (2002) [Pubmed]
 
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