The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

EFNA1  -  ephrin-A1

Homo sapiens

Synonyms: B61, ECKLG, EFL1, EPH-related receptor tyrosine kinase ligand 1, EPLG1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of EFNA1


High impact information on EFNA1


Chemical compound and disease context of EFNA1

  • In particular, dehydration stress led to slightly reduced levels of B61 RNA, and ABA application to young seedlings had no marked effect on its abundance [9].

Biological context of EFNA1


Anatomical context of EFNA1

  • In contrast, EFNA1 was detected in all cell lines [1].
  • Here we demonstrate that CD4+ T lymphocytes express the EphA1 and EphA4 receptors and that these cells bind the ligand ephrin-A1 [11].
  • This, together with our finding that ephrin-A1 is expressed by HEV endothelial cells, suggests a role for Eph receptors in transendothelial migration [11].
  • These results suggest that the Eck-B61 interaction, a target of regulatory peptides, plays a role in intestinal epithelial cell development, migration, and barrier function, contributing to homeostasis and preservation of continuity of the epithelial barrier [13].
  • HT29 cells were transfected with EFNA1 antisense yielding clones that expressed less than 25% of EFNA1 found in vector controls [14].

Associations of EFNA1 with chemical compounds

  • An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein [15].
  • Interactions between these molecules are promiscuous, but largely fall into two groups: EphA receptors bind to glycosylphosphatidyl inositol-anchored ephrin-A ligands, and EphB receptors bind to transmembrane ephrin-B proteins [16].
  • Immunohistochemical examination showed that ephrin A1 was expressed on human endometrial luminal and glandular epithelial cells in both the proliferative (cycle d 8-13; n = 8) and secretory (cycle d 18-24; n = 7) phases [17].

Regulatory relationships of EFNA1


Other interactions of EFNA1


Analytical, diagnostic and therapeutic context of EFNA1


  1. EPHA2/EFNA1 expression in human gastric cancer. Nakamura, R., Kataoka, H., Sato, N., Kanamori, M., Ihara, M., Igarashi, H., Ravshanov, S., Wang, Y.J., Li, Z.Y., Shimamura, T., Kobayashi, T., Konno, H., Shinmura, K., Tanaka, M., Sugimura, H. Cancer Sci. (2005) [Pubmed]
  2. Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. Varelias, A., Koblar, S.A., Cowled, P.A., Carter, C.D., Clayer, M. Cancer (2002) [Pubmed]
  3. Up-regulation of ephrin-A1 during melanoma progression. Easty, D.J., Hill, S.P., Hsu, M.Y., Fallowfield, M.E., Florenes, V.A., Herlyn, M., Bennett, D.C. Int. J. Cancer (1999) [Pubmed]
  4. Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder. Abraham, S., Knapp, D.W., Cheng, L., Snyder, P.W., Mittal, S.K., Bangari, D.S., Kinch, M., Wu, L., Dhariwal, J., Mohammed, S.I. Clin. Cancer Res. (2006) [Pubmed]
  5. Local axon guidance in cerebral cortex and thalamus: are we there yet? Grove, E.A. Neuron (2005) [Pubmed]
  6. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Miao, H., Wei, B.R., Peehl, D.M., Li, Q., Alexandrou, T., Schelling, J.R., Rhim, J.S., Sedor, J.R., Burnett, E., Wang, B. Nat. Cell Biol. (2001) [Pubmed]
  7. EphA kinase activation regulates HGF-induced epithelial branching morphogenesis. Miao, H., Nickel, C.H., Cantley, L.G., Bruggeman, L.A., Bennardo, L.N., Wang, B. J. Cell Biol. (2003) [Pubmed]
  8. Homeobox B3 promotes capillary morphogenesis and angiogenesis. Myers, C., Charboneau, A., Boudreau, N. J. Cell Biol. (2000) [Pubmed]
  9. A dehydrin cognate protein from pea (Pisum sativum L.) with an atypical pattern of expression. Robertson, M., Chandler, P.M. Plant Mol. Biol. (1994) [Pubmed]
  10. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Cerretti, D.P., Lyman, S.D., Kozlosky, C.J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Valentine, V., Kirstein, M.N., Shapiro, D.N., Morris, S.W. Genomics (1996) [Pubmed]
  11. Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2. Aasheim, H.C., Delabie, J., Finne, E.F. Blood (2005) [Pubmed]
  12. Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells. Sharfe, N., Freywald, A., Toro, A., Roifman, C.M. J. Immunol. (2003) [Pubmed]
  13. Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function. Rosenberg, I.M., Göke, M., Kanai, M., Reinecker, H.C., Podolsky, D.K. Am. J. Physiol. (1997) [Pubmed]
  14. Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells. Potla, L., Boghaert, E.R., Armellino, D., Frost, P., Damle, N.K. Cancer Lett. (2002) [Pubmed]
  15. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. Huai, J., Drescher, U. J. Biol. Chem. (2001) [Pubmed]
  16. Roles of Eph receptors and ephrins in segmental patterning. Xu, Q., Mellitzer, G., Wilkinson, D.G. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2000) [Pubmed]
  17. Human endometrial epithelial cells express ephrin A1: possible interaction between human blastocysts and endometrium via Eph-ephrin system. Fujiwara, H., Yoshioka, S., Tatsumi, K., Kosaka, K., Satoh, Y., Nishioka, Y., Egawa, M., Higuchi, T., Fujii, S. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  18. Ephrin stimulation modulates T cell chemotaxis. Sharfe, N., Freywald, A., Toro, A., Dadi, H., Roifman, C. Eur. J. Immunol. (2002) [Pubmed]
  19. Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism. Cheng, N., Chen, J. J. Biol. Chem. (2001) [Pubmed]
  20. Ephrin-A1 expression contributes to the malignant characteristics of {alpha}-fetoprotein producing hepatocellular carcinoma. Iida, H., Honda, M., Kawai, H.F., Yamashita, T., Shirota, Y., Wang, B.C., Miao, H., Kaneko, S. Gut (2005) [Pubmed]
  21. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. Tang, X.X., Pleasure, D.E., Ikegaki, N. Genomics (1997) [Pubmed]
  22. Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. Lackmann, M., Mann, R.J., Kravets, L., Smith, F.M., Bucci, T.A., Maxwell, K.F., Howlett, G.J., Olsson, J.E., Vanden Bos, T., Cerretti, D.P., Boyd, A.W. J. Biol. Chem. (1997) [Pubmed]
  23. Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1 and ephrin-A1/EphA2 on melanoma progression. Straume, O., Akslen, L.A. Am. J. Pathol. (2002) [Pubmed]
  24. Inhibition of retinal neovascularization by soluble EphA2 receptor. Chen, J., Hicks, D., Brantley-Sieders, D., Cheng, N., McCollum, G.W., Qi-Werdich, X., Penn, J. Exp. Eye Res. (2006) [Pubmed]
WikiGenes - Universities