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Gene Review

narH  -  nitrate reductase 1, beta (Fe-S) subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1219, JW1216, chlC
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Disease relevance of narH


High impact information on narH

  • Previous studies established that the first two genes in the operon narG and narH encode the alpha and beta subunits, respectively, while formation of the gamma subunit, cytochrome bNR, depends on expression of the promoter distal genes [4].
  • The results indicated that the genes encoding the alpha and beta subunits of nitrate reductase were part of a chlC (nar) operon that is transcribed in the direction alpha leads to beta [5].
  • Gene fusions between the lac structural genes and the chlC locus were isolated, and the regulation of lac gene expression was studied [6].
  • Five temperature-sensitive chlC mutants were isolated from Escherichia coli by the technique of localized mutagenesis [7].

Biological context of narH


Associations of narH with chemical compounds

  • Analysis of the chlC (narC) mutant, defective in the structural gene for nitrate reductase, revealed that heat treatment is not necessary for the expression of the active component [9].

Analytical, diagnostic and therapeutic context of narH


  1. The narJ gene product is required for biogenesis of respiratory nitrate reductase in Escherichia coli. Dubourdieu, M., DeMoss, J.A. J. Bacteriol. (1992) [Pubmed]
  2. Sequence analysis of subunits of the membrane-bound nitrate reductase from a denitrifying bacterium: the integral membrane subunit provides a prototype for the dihaem electron-carrying arm of a redox loop. Berks, B.C., Page, M.D., Richardson, D.J., Reilly, A., Cavill, A., Outen, F., Ferguson, S.J. Mol. Microbiol. (1995) [Pubmed]
  3. Nitrate reductase and cytochrome bnitrate reductase structural genes as parts of the nitrate reductase operon. Bonnefoy-Orth, V., Lepelletier, M., Pascal, M.C., Chippaux, M. Mol. Gen. Genet. (1981) [Pubmed]
  4. Roles of the narJ and narI gene products in the expression of nitrate reductase in Escherichia coli. Sodergren, E.J., Hsu, P.Y., DeMoss, J.A. J. Biol. Chem. (1988) [Pubmed]
  5. chlC (nar) operon of Escherichia coli includes structural genes for alpha and beta subunits of nitrate reductase. Edwards, E.S., Rondeau, S.S., DeMoss, J.A. J. Bacteriol. (1983) [Pubmed]
  6. Use of chlC-lac fusions to determine regulation of gene chlC in Escherichia coli K-12. Fimmel, A.L., Haddock, B.A. J. Bacteriol. (1979) [Pubmed]
  7. Role of the chlC gene in formation of the formate-nitrate reductase pathway in Escherichia coli. DeMoss, J.A. J. Bacteriol. (1978) [Pubmed]
  8. Purification of the dissimilative nitrate reductase of Pseudomonas fluorescens and the cloning and sequencing of its corresponding genes. Philippot, L., Clays-Josserand, A., Lensi, R., Trinsoutreau, I., Normand, P., Potier, P. Biochim. Biophys. Acta (1997) [Pubmed]
  9. Activation in vitro of respiratory nitrate reductase of Escherichia coli K12 grown in the presence of tungstate. Involvement of molybdenum cofactor. Saracino, L., Violet, M., Boxer, D.H., Giordano, G. Eur. J. Biochem. (1986) [Pubmed]
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