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Gene Review

ftsW  -  putative lipid II flippase; integral...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0090, JW0087
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Disease relevance of ftsW


High impact information on ftsW

  • In the absence of exogenous promoters, plasmid-mediated complementation of the temperature-sensitive ftsW201 allele requires the presence of the full coding sequence of ftsW plus upstream DNA encompassing the C-terminus of mraY and the full coding sequence of murD [1].
  • In the absence of arabinose, the ftsW-null strain is not viable, and a shift from arabinose- to glucose-containing liquid medium resulted in a block in division, followed by cell lysis [1].
  • We also demonstrated that the expression of only ftsWS (the smaller of two ftsW open reading frames) from P(BAD) is sufficient for complementation of the ftsW-null allele [1].
  • Hybridization of mRNA from C68, CV133, and four ampicillin-resistant CV133 mutants revealed four distinct transcripts from this region, consisting of (i) E. faecium ftsW (ftsW(Efm)) alone; (ii) psr and pbp5; (iii) pbp5 alone; and (iv) ftsW(Efm), psr, and pbp5 [2].
  • A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW [3].

Biological context of ftsW


Analytical, diagnostic and therapeutic context of ftsW

  • Immunofluorescence microscopy revealed that in ftsW-null filaments, the FtsZ ring is absent in 50-60% of filaments, whilst between one and three Z-rings per filament can be detected in the remainder of the population, with the majority of these containing only one Z-ring per filament [1].
  • We used molecular and genetic techniques to introduce an insertional inactivation into the chromosomal copy of ftsW, in the presence of the plasmid-borne wild-type ftsW gene under the control of P(BAD) [1].
  • Complementation tests suggest that they extend into ftsW in the central part of the cluster [5].


  1. ftsW is an essential cell-division gene in Escherichia coli. Boyle, D.S., Khattar, M.M., Addinall, S.G., Lutkenhaus, J., Donachie, W.D. Mol. Microbiol. (1997) [Pubmed]
  2. Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium. Rice, L.B., Carias, L.L., Hutton-Thomas, R., Sifaoui, F., Gutmann, L., Rudin, S.D. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW. Hara, H., Yasuda, S., Horiuchi, K., Park, J.T. J. Bacteriol. (1997) [Pubmed]
  4. The analysis of cell division and cell wall synthesis genes reveals mutationally inactivated ftsQ and mraY in a protoplast-type L-form of Escherichia coli. Siddiqui, R.A., Hoischen, C., Holst, O., Heinze, I., Schlott, B., Gumpert, J., Diekmann, S., Grosse, F., Platzer, M. FEMS Microbiol. Lett. (2006) [Pubmed]
  5. Regulation of transcription of cell division genes in the Escherichia coli dcw cluster. Vicente, M., Gomez, M.J., Ayala, J.A. Cell. Mol. Life Sci. (1998) [Pubmed]
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