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Gene Review

ftsA  -  ATP-binding cell division FtsK recruitment...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0095, JW0092, divA
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Disease relevance of ftsA


High impact information on ftsA


Chemical compound and disease context of ftsA


Biological context of ftsA


Anatomical context of ftsA


Associations of ftsA with chemical compounds

  • After cloning the ftsA region from a strain containing the spoIIN279(ts) mutation we found that this mutation converts the ninth residue of the FtsA protein from serine to asparagine [18].
  • Sublethal Concentrations of the Aminoglycoside Amikacin Interfere with Cell Division without Affecting Chromosome Dynamics [19].
  • Cell division in particular appears very sensitive to the level of cell Ca(2+), with the frequency of division clearly reduced by EGTA and by verapamil [20].
  • This chloramphenicol treatment of ftsA-3 filaments (previously designated at divA) does not induce cell division but does induce cell lysis [21].

Physical interactions of ftsA

  • The observation that the termination codon of ftsQ overlaps with a potential initiation codon for ftsA suggested that these two genes may be translationally coupled when transcription is initiated upstream of the ftsQ coding sequence [13].

Regulatory relationships of ftsA

  • We have previously shown that ftsA can be expressed from a weak promoter located within the ftsQ gene (Robinson et al., J. Bacteriol. 160:546-555, 1984) [22].

Other interactions of ftsA


Analytical, diagnostic and therapeutic context of ftsA


  1. Structure and expression of the cell division genes ftsQ, ftsA and ftsZ. Yi, Q.M., Rockenbach, S., Ward, J.E., Lutkenhaus, J. J. Mol. Biol. (1985) [Pubmed]
  2. Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle. Sackett, M.J., Kelly, A.J., Brun, Y.V. Mol. Microbiol. (1998) [Pubmed]
  3. Cell division in cocci: localization and properties of the Streptococcus pneumoniae FtsA protein. Lara, B., Rico, A.I., Petruzzelli, S., Santona, A., Dumas, J., Biton, J., Vicente, M., Mingorance, J., Massidda, O. Mol. Microbiol. (2005) [Pubmed]
  4. Post-antibiotic effects of ofloxacin on Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes. Howard, B.M., Pinney, R.J., Smith, J.T. Chemotherapy. (1993) [Pubmed]
  5. A widely conserved bacterial cell division protein that promotes assembly of the tubulin-like protein FtsZ. Gueiros-Filho, F.J., Losick, R. Genes Dev. (2002) [Pubmed]
  6. A gain-of-function mutation in ftsA bypasses the requirement for the essential cell division gene zipA in Escherichia coli. Geissler, B., Elraheb, D., Margolin, W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation. Huisman, O., D'Ari, R., Gottesman, S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  8. The P1 plasmid is segregated to daughter cells by a 'capture and ejection' mechanism coordinated with Escherichia coli cell division. Li, Y., Austin, S. Mol. Microbiol. (2002) [Pubmed]
  9. Transcription of essential cell division genes is linked to chromosome replication in Escherichia coli. Liu, G., Begg, K., Geddes, A., Donachie, W.D. Mol. Microbiol. (2001) [Pubmed]
  10. Interaction of FtsA and PBP3 proteins in the Escherichia coli septum. Tormo, A., Ayala, J.A., de Pedro, M.A., Aldea, M., Vicente, M. J. Bacteriol. (1986) [Pubmed]
  11. On the mode of action of 5-diazouracil on bacterial cell division. Coates, D.A., Rowbury, R.J. Chem. Biol. Interact. (1976) [Pubmed]
  12. Induction of cell division in a temperature-sensitive division mutant of Escherichia coli by inhibition of protein synthesis. de Pedro, M.A., Cánovas, J.L. J. Gen. Microbiol. (1977) [Pubmed]
  13. DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units. Robinson, A.C., Kenan, D.J., Hatfull, G.F., Sullivan, N.F., Spiegelberg, R., Donachie, W.D. J. Bacteriol. (1984) [Pubmed]
  14. The analysis of cell division and cell wall synthesis genes reveals mutationally inactivated ftsQ and mraY in a protoplast-type L-form of Escherichia coli. Siddiqui, R.A., Hoischen, C., Holst, O., Heinze, I., Schlott, B., Gumpert, J., Diekmann, S., Grosse, F., Platzer, M. FEMS Microbiol. Lett. (2006) [Pubmed]
  15. High-level expression of the FtsA protein inhibits cell septation in Escherichia coli K-12. Wang, H.C., Gayda, R.C. J. Bacteriol. (1990) [Pubmed]
  16. Quantitative determination of FtsA at different growth rates in Escherichia coli using monoclonal antibodies. Wang, H., Gayda, R.C. Mol. Microbiol. (1992) [Pubmed]
  17. Hypothesis: a phospholipid translocase couples lateral and transverse bilayer asymmetries in dividing bacteria. Norris, V., Misevic, G., Delosme, J.M., Oshima, A. J. Mol. Biol. (2002) [Pubmed]
  18. The spoIIN279(ts) mutation affects the FtsA protein of Bacillus subtilis. Karmazyn-Campelli, C., Fluss, L., Leighton, T., Stragier, P. Biochimie (1992) [Pubmed]
  19. Sublethal Concentrations of the Aminoglycoside Amikacin Interfere with Cell Division without Affecting Chromosome Dynamics. Possoz, C., Newmark, J., Sorto, N., Sherratt, D.J., Tolmasky, M.E. Antimicrob. Agents Chemother. (2007) [Pubmed]
  20. An assessment of the role of intracellular free Ca2+ in E. coli. Holland, I.B., Jones, H.E., Campbell, A.K., Jacq, A. Biochimie (1999) [Pubmed]
  21. Influence of the genetic background on cell division and cell lysis: behaviour of different Escherichia coli strains carrying the ts-52 or the ftsA-3 mutation. Tormo, A., Fenoll, C. Microbios (1985) [Pubmed]
  22. Regulation of expression of the ftsA cell division gene by sequences in upstream genes. Dewar, S.J., Donachie, W.D. J. Bacteriol. (1990) [Pubmed]
  23. Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two-component system rcsC-rcsB. Carballès, F., Bertrand, C., Bouché, J.P., Cam, K. Mol. Microbiol. (1999) [Pubmed]
  24. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. Taschner, P.E., Huls, P.G., Pas, E., Woldringh, C.L. J. Bacteriol. (1988) [Pubmed]
  25. The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli. Yi, Q.M., Lutkenhaus, J. Gene (1985) [Pubmed]
  26. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. Lau, S.Y., Zgurskaya, H.I. J. Bacteriol. (2005) [Pubmed]
  27. Nucleotide sequence and insertional inactivation of a Bacillus subtilis gene that affects cell division, sporulation, and temperature sensitivity. Beall, B., Lutkenhaus, J. J. Bacteriol. (1989) [Pubmed]
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