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Gene Review

murF  -  UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0087, JW0084, mra
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Disease relevance of murF


High impact information on murF


Biological context of murF


Associations of murF with chemical compounds

  • The D-alanyl-D-alanine-adding enzyme encoded by the murF gene catalyzes the ATP-dependent formation of UDP-N-acetylmuramyl-L-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala (UDP-MurNAc-tripeptide) [10].
  • The Actinoplanes teichomyceticus tcp cluster, devoted to the biosynthesis of the glycopeptide antibiotic teicoplanin, contains van genes associated to a murF-like sequence (murF2) [11].

Other interactions of murF


  1. Contribution of the Pmra promoter to expression of genes in the Escherichia coli mra cluster of cell envelope biosynthesis and cell division genes. Mengin-Lecreulx, D., Ayala, J., Bouhss, A., van Heijenoort, J., Parquet, C., Hara, H. J. Bacteriol. (1998) [Pubmed]
  2. The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: cloning, production, and purification of active enzymes. Azzolina, B.A., Yuan, X., Anderson, M.S., El-Sherbeini, M. Protein Expr. Purif. (2001) [Pubmed]
  3. Characterization of the murF gene of the cyanobacterium Synechocystis sp. PCC 6803. Malakhov, M.P., Los, D.A., Wada, H., Semenenko, V.E., Murata, N. Microbiology (Reading, Engl.) (1995) [Pubmed]
  4. Nucleotide sequence involving murG and murC in the mra gene cluster region of Escherichia coli. Ikeda, M., Wachi, M., Jung, H.K., Ishino, F., Matsuhashi, M. Nucleic Acids Res. (1990) [Pubmed]
  5. Nucleotide sequence involving murD and an open reading frame ORF-Y spacing murF and ftsW in Escherichia coli. Ikeda, M., Wachi, M., Ishino, F., Matsuhashi, M. Nucleic Acids Res. (1990) [Pubmed]
  6. Nucleotide sequence of the murF gene encoding the UDP-MurNAc-pentapeptide synthetase of Escherichia coli. Parquet, C., Flouret, B., Mengin-Lecreulx, D., van Heijenoort, J. Nucleic Acids Res. (1989) [Pubmed]
  7. Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamily. Eveland, S.S., Pompliano, D.L., Anderson, M.S. Biochemistry (1997) [Pubmed]
  8. A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW. Hara, H., Yasuda, S., Horiuchi, K., Park, J.T. J. Bacteriol. (1997) [Pubmed]
  9. Control of division gene expression in Escherichia coli. Dewar, S.J., Dorazi, R. FEMS Microbiol. Lett. (2000) [Pubmed]
  10. Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion. Anderson, M.S., Eveland, S.S., Onishi, H.R., Pompliano, D.L. Biochemistry (1996) [Pubmed]
  11. Glycopeptide resistance determinants from the teicoplanin producer Actinoplanes teichomyceticus. Serina, S., Radice, F., Maffioli, S., Donadio, S., Sosio, M. FEMS Microbiol. Lett. (2004) [Pubmed]
  12. Determination of gene products and coding regions from the murE-murF region of Escherichia coli. Maruyama, I.N., Yamamoto, A.H., Hirota, Y. J. Bacteriol. (1988) [Pubmed]
  13. New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division. Ishino, F., Jung, H.K., Ikeda, M., Doi, M., Wachi, M., Matsuhashi, M. J. Bacteriol. (1989) [Pubmed]
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