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Gene Review

cheW1  -  chemotaxis protein

Sinorhizobium meliloti 1021

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Disease relevance of cheW1

  • Different roles of CheY1 and CheY2 in the chemotaxis of Rhizobium meliloti [1].
  • A large chemotaxis operon was identified in Rhodobacter sphaeroides WS8-N using a probe based on the 3' terminal portion of the Rhizobium meliloti cheA gene [2].
  • Unlike in E. coli, however, Glu150 is essential for torque generation, whereas residues Arg90 and Glu98 are crucial for the chemotaxis-controlled variation of rotary speed [3].
  • Rem, a New Transcriptional Activator of Motility and Chemotaxis in Sinorhizobium meliloti [4].
  • These two mutant strains could not be classified according to the generally accepted model for a sensory pathway, derived from studies of enteric bacteria, and provided evidence for a dual chemotaxis pathway in R. meliloti [5].

High impact information on cheW1

  • Analysis of a chemotaxis operon in Rhizobium meliloti [6].
  • Genes controlling chemotaxis towards L-amino acids and D-mannitol in Rhizobium meliloti have been identified by Tn5 insertions that lead to chemotaxis-deficient mutants [6].
  • Therefore, it is postulated that two chemotaxis pathways are functional in R. meliloti: one responds to L-amino acids via ORF1-ORF2, whereas the other (probably responding to specific plant exudates) acts via MCP-like receptors, and both interact with the central components CheW-CheA-CheY1 and/or CheY2 [6].
  • The majority, however, code for proteins predicted to be involved in a wide variety of functions not previously recognized to play a role in LPS synthesis, including a possible transcription elongation factor (GreA), a possible queuine synthesis protein, and a possible chemotaxis protein [7].
  • It is concluded that between 80 and 90% of the genes responsible for chemotaxis and motility are located in a single region of the S. meliloti chromosome near the his-39 marker [8].

Chemical compound and disease context of cheW1


Biological context of cheW1


Associations of cheW1 with chemical compounds

  • Repression was observed for 8 genes related to motility and chemotaxis, 7 genes encoding amino acid biosynthesis enzymes and 15 genes involved in iron uptake whereas 14 genes involved in transport of small molecules and 4 genes related to polysaccharide biosynthesis were induced [10].
  • (i) In addition to six transmembrane chemotaxis receptors, S. meliloti has two cytoplasmic receptor proteins, McpY (methyl-accepting chemotaxis protein) and IcpA (internal chemotaxis protein) [11].

Analytical, diagnostic and therapeutic context of cheW1

  • Based on DNA microarray data, the Sin system also seems to regulate a multitude of S. meliloti genes, including genes that participate in low-molecular-weight succinoglycan production, motility, and chemotaxis, as well as other cellular processes [12].


  1. Different roles of CheY1 and CheY2 in the chemotaxis of Rhizobium meliloti. Sourjik, V., Schmitt, R. Mol. Microbiol. (1996) [Pubmed]
  2. Identification of a chemotaxis operon with two cheY genes in Rhodobacter sphaeroides. Ward, M.J., Bell, A.W., Hamblin, P.A., Packer, H.L., Armitage, J.P. Mol. Microbiol. (1995) [Pubmed]
  3. Control of speed modulation (chemokinesis) in the unidirectional rotary motor of Sinorhizobium meliloti. Attmannspacher, U., Scharf, B., Schmitt, R. Mol. Microbiol. (2005) [Pubmed]
  4. Rem, a New Transcriptional Activator of Motility and Chemotaxis in Sinorhizobium meliloti. Rotter, C., Mühlbacher, S., Salamon, D., Schmitt, R., Scharf, B. J. Bacteriol. (2006) [Pubmed]
  5. Physiology of behavioral mutants of Rhizobium meliloti: evidence for a dual chemotaxis pathway. Bergman, K., Gulash-Hoffee, M., Hovestadt, R.E., Larosiliere, R.C., Ronco, P.G., Su, L. J. Bacteriol. (1988) [Pubmed]
  6. Analysis of a chemotaxis operon in Rhizobium meliloti. Greck, M., Platzer, J., Sourjik, V., Schmitt, R. Mol. Microbiol. (1995) [Pubmed]
  7. Striking complexity of lipopolysaccharide defects in a collection of Sinorhizobium meliloti mutants. Campbell, G.R., Sharypova, L.A., Scheidle, H., Jones, K.M., Niehaus, K., Becker, A., Walker, G.C. J. Bacteriol. (2003) [Pubmed]
  8. Mapping of 41 chemotaxis, flagellar and motility genes to a single region of the Sinorhizobium meliloti chromosome. Sourjik, V., Sterr, W., Platzer, J., Bos, I., Haslbeck, M., Schmitt, R. Gene (1998) [Pubmed]
  9. Relationships between C4 dicarboxylic acid transport and chemotaxis in Rhizobium meliloti. Robinson, J.B., Bauer, W.D. J. Bacteriol. (1993) [Pubmed]
  10. Construction and validation of a Sinorhizobium meliloti whole genome DNA microarray: genome-wide profiling of osmoadaptive gene expression. Rüberg, S., Tian, Z.X., Krol, E., Linke, B., Meyer, F., Wang, Y., Pühler, A., Weidner, S., Becker, A. J. Biotechnol. (2003) [Pubmed]
  11. Sensory transduction to the flagellar motor of Sinorhizobium meliloti. Scharf, B., Schmitt, R. J. Mol. Microbiol. Biotechnol. (2002) [Pubmed]
  12. The LuxR homolog ExpR, in combination with the Sin quorum sensing system, plays a central role in Sinorhizobium meliloti gene expression. Hoang, H.H., Becker, A., González, J.E. J. Bacteriol. (2004) [Pubmed]
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