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Gene Review

ccmD  -  cytochrome c biogenesis protein; heme...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2190, JW2186, yojM
 
 
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Disease relevance of ccmD

 

High impact information on ccmD

  • This is strong evidence for disulfide bond formation involving the two cysteine residues of apocytochrome c as an intermediate in Ccm-type Gram-negative bacterial cytochrome c biogenesis and/or that only a pair of cysteines can be recognized by the heme attachment apparatus [5].
  • Enhanced expression of ccmD suppressed this mutant phenotype by increasing the amounts of CcmC and CcmE polypeptides in the membrane [6].
  • Similarities between haems of the cytochrome c biogenesis nrf pathway and iron bleomycin suggest a DNA repair-independent molecular mechanism for both bleomycin resistance and increased viability [7].
  • Cytochrome c biogenesis describes the posttranslational pathway for the conversion of pre-apocytochrome c into the mature holocytochrome c. It involves an unknown number of consecutive biochemical steps, including translocation of the precursor polypeptide and haem into the periplasm and the covalent linkage between these two molecules [8].
  • Spectral analysis, heme-associated peroxidase activities, and respiratory activities of the cell membranes revealed that the ccm genes of G. diazotrophicus are involved in cytochrome c biogenesis [4].
 

Chemical compound and disease context of ccmD

 

Biological context of ccmD

References

  1. A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens. Yang, C.H., Azad, H.R., Cooksey, D.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. A thioreduction pathway tethered to the membrane for periplasmic cytochromes c biogenesis; in vitro and in vivo studies. Monika, E.M., Goldman, B.S., Beckman, D.L., Kranz, R.G. J. Mol. Biol. (1997) [Pubmed]
  3. The dithiol:disulfide oxidoreductases DsbA and DsbB of Rhodobacter capsulatus are not directly involved in cytochrome c biogenesis, but their inactivation restores the cytochrome c biogenesis defect of CcdA-null mutants. Deshmukh, M., Turkarslan, S., Astor, D., Valkova-Valchanova, M., Daldal, F. J. Bacteriol. (2003) [Pubmed]
  4. Indole-3-acetic acid biosynthesis is deficient in Gluconacetobacter diazotrophicus strains with mutations in cytochrome c biogenesis genes. Lee, S., Flores-Encarnación, M., Contreras-Zentella, M., Garcia-Flores, L., Escamilla, J.E., Kennedy, C. J. Bacteriol. (2004) [Pubmed]
  5. The Escherichia coli cytochrome c maturation (Ccm) system does not detectably attach heme to single cysteine variants of an apocytochrome c. Allen, J.W., Tomlinson, E.J., Hong, L., Ferguson, S.J. J. Biol. Chem. (2002) [Pubmed]
  6. New insights into the role of CcmC, CcmD and CcmE in the haem delivery pathway during cytochrome c maturation by a complete mutational analysis of the conserved tryptophan-rich motif of CcmC. Schulz, H., Pellicioli, E.C., Thöny-Meyer, L. Mol. Microbiol. (2000) [Pubmed]
  7. Cytochrome c biogenesis is involved in the transposon Tn5-mediated bleomycin resistance and the associated fitness effect in Escherichia coli. Adam, E., Volkert, M.R., Blot, M. Mol. Microbiol. (1998) [Pubmed]
  8. Cytochrome c biogenesis in bacteria: a possible pathway begins to emerge. Thöny-Meyer, L., Ritz, D., Hennecke, H. Mol. Microbiol. (1994) [Pubmed]
  9. Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum. Delgado, M.J., Yeoman, K.H., Wu, G., Vargas, C., Davies, A.E., Poole, R.K., Johnston, A.W., Downie, J.A. J. Bacteriol. (1995) [Pubmed]
 
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