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Gene Review

rpiA  -  ribose 5-phosphate isomerase, constitutive

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2910, JW5475, ygfC
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Disease relevance of rpiA


High impact information on rpiA

  • In addition, strain A145 was a ribose auxotroph, as expected for an rpiA mutant [2].
  • Experiments reported here indicate a key role for rpiA and possibly the pentose phosphate pathway in suppression of damping-off and colonization of subterranean portions of plants by E. cloacae [2].
  • Molecular characterization of strain A145 indicated mini-Tn5 Km was inserted in a region of the E. cloacae genome with a high degree of DNA and amino acid sequence similarity to rpiA, which encodes ribose-5-phosphate isomerase [2].
  • Escherichia coli strains defective in the rpiA gene, encoding ribose phosphate isomerase A, are ribose auxotrophs, despite the presence of the wild-type rpiB gene, which encodes ribose phosphate isomerase B. Ribose prototrophs of an rpiA genetic background were isolated by two different approaches [3].
  • Host strains harboring the rpiA gene in a multicopy plasmid contained up to 42-fold as much ribose phosphate isomerase A activity as the haploid strain [1].

Biological context of rpiA

  • The rpiA gene was cloned into an expression vector to construct plasmid pETrpiA [4].


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