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Gene Review

fusA  -  protein chain elongation factor EF-G, GTP...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3327, JW3302, far, fus
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Disease relevance of fusA


High impact information on fusA

  • We have previously identified 20 different fusidic acid-resistant alleles of fusA, encoding mutant forms of the ribosomal translocase EF-G [4].
  • The mutations conferred cross-resistance to fusidic acid and mapped in fusA, the gene encoding elongation factor G. Cross-resistance between cephalosporin P1 and fusidic acid also occurred for S. aureus fusA mutants selected with fusidic acid, and in fusidic acid-resistant clinical isolates [5].
  • In contrast, mutations in 10 mutants selected with cephalosporin P1 were all located in fusA [5].
  • The removal of an EcoRI fragment that lies within fus destroyed the ability of the 2,000-base-pair PstI-SmaI fragment to promote the transcription of tet [6].
  • This region is almost certainly equivalent to the rif locus, located near to fus at interval 12/13 on the S. aureus linkage map [7].

Biological context of fusA

  • Measurements of transcription rates from various regions of the str operon in cells carrying the fus gene and the beginning of the tufA gene on a high copy number plasmid confirmed that transcription was initiated within a 600 bp EcoRI fragment in the distal portion of the fus gene [8].


  1. The nucleotide sequence of the Escherichia coli fus gene, coding for elongation factor G. Zengel, J.M., Archer, R.H., Lindahl, L. Nucleic Acids Res. (1984) [Pubmed]
  2. Specialized transducing phages for ribosomal protein genes of Escherichia coli. Jaskunas, S.R., Lindahl, L., Nomura, M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  3. A chimeric disposition of the elongation factor genes in Rickettsia prowazekii. Syvänen, A.C., Amiri, H., Jamal, A., Andersson, S.G., Kurland, C.G. J. Bacteriol. (1996) [Pubmed]
  4. The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants. Johanson, U., Aevarsson, A., Liljas, A., Hughes, D. J. Mol. Biol. (1996) [Pubmed]
  5. Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid. O'Neill, A.J., Bostock, J.M., Moita, A.M., Chopra, I. J. Antimicrob. Chemother. (2002) [Pubmed]
  6. Evidence for an internal promoter preceding tufA in the str operon of Escherichia coli. An, G., Lee, J.S., Friesen, J.D. J. Bacteriol. (1982) [Pubmed]
  7. Cloning and physical mapping of the Staphylococcus aureus rplL, rpoB and rpoC genes, encoding ribosomal protein L7/L12 and RNA polymerase subunits beta and beta'. Aboshkiwa, M., al-Ani, B., Coleman, G., Rowland, G. J. Gen. Microbiol. (1992) [Pubmed]
  8. Mapping of two promoters for elongation factor Tu within the structural gene for elongation factor G. Zengel, J.M., Lindahl, L. Biochim. Biophys. Acta (1990) [Pubmed]
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