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Gene Review

cysG  -  fused siroheme synthase 1,3...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3356, JW3331
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Disease relevance of cysG

  • Transcriptional control of the cysG gene of Escherichia coli K-12 during aerobic and anaerobic growth [1].
  • All previously known Salmonella cysG mutants are defective in the synthesis of both siroheme and cobalamin [2].

High impact information on cysG

  • The cysG gene product is expressed from both p-nirB and a second, FNR-independent promoter, p-cysG, located within the nirC gene [3].
  • Overproduction of ZmSUMT1 in a cysG mutant of E. coli eliminated the requirement of the strain for cysteine [4].
  • Taken together, the results show that the cysG promoter belongs to the 'extended -10' class of promoters, and the base sequence is similar to that of the P1 promoter of the E. coli galactose operon, another promoter in this class [5].
  • The DNAase I footprint of RNA polymerase at the cysG promoter reveals extended protection upstream of the transcript start, and studies with potassium permanganate as a probe suggest that the upstream region is distorted in open complexes [5].
  • The cysG gene of Salmonella typhimurium is involved in synthesis of both cobalamin (B12) and siroheme (a cofactor required for SO3(2-) and NO2(2-) reductases) [2].

Chemical compound and disease context of cysG


Biological context of cysG


Associations of cysG with chemical compounds

  • Rates of transcription from the isolated cysG promoter were the same during aerobic growth and anaerobic growth in the presence or absence of nitrite [1].

Other interactions of cysG

  • Further analysis revealed that the ftsD220 mapped at min 73 and that it is linked to cysG (6%) and to aroB (39%) [8].


  1. Transcriptional control of the cysG gene of Escherichia coli K-12 during aerobic and anaerobic growth. Peakman, T., Busby, S., Cole, J. Eur. J. Biochem. (1990) [Pubmed]
  2. Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt. Fazzio, T.G., Roth, J.R. J. Bacteriol. (1996) [Pubmed]
  3. Transcriptional control, translation and function of the products of the five open reading frames of the Escherichia coli nir operon. Harborne, N.R., Griffiths, L., Busby, S.J., Cole, J.A. Mol. Microbiol. (1992) [Pubmed]
  4. Isolation and characterization of a cDNA that encodes maize uroporphyrinogen III methyltransferase, an enzyme involved in the synthesis of siroheme, which is prosthetic group of nitrite reductase. Sakakibara, H., Takei, K., Sugiyama, T. Plant J. (1996) [Pubmed]
  5. The Escherichia coli cysG promoter belongs to the 'extended -10' class of bacterial promoters. Belyaeva, T., Griffiths, L., Minchin, S., Cole, J., Busby, S. Biochem. J. (1993) [Pubmed]
  6. Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome. Peakman, T., Crouzet, J., Mayaux, J.F., Busby, S., Mohan, S., Harborne, N., Wootton, J., Nicolson, R., Cole, J. Eur. J. Biochem. (1990) [Pubmed]
  7. Enzymatic synthesis of dihydrosirohydrochlorin (precorrin-2) and of a novel pyrrocorphin by uroporphyrinogen III methylase. Warren, M.J., Stolowich, N.J., Santander, P.J., Roessner, C.A., Sowa, B.A., Scott, A.I. FEBS Lett. (1990) [Pubmed]
  8. Fts insertional mutant of Salmonella typhimurium. Cerquetti, M.C., Brawer, R., Gerdes, C.A., Gherardi, M.M., Sordelli, D.O. FEMS Microbiol. Lett. (1995) [Pubmed]
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