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Gene Review

malM  -  maltose regulon periplasmic protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4029, JW3997, molA
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Disease relevance of malM


High impact information on malM


Chemical compound and disease context of malM


Biological context of malM

  • In a recipient strain deleted in the mal region of its chromosome, these constructs gave Mal+ transformants in which the malM and sul genes were now linked, with malM located between duplicate sul segments [8].

Associations of malM with chemical compounds

  • Examination of malM mutant reversion frequencies in ung strains indicated that G.C----A.T mutation rates generally were 10-fold higher than in wild-type strains, presumably owing to lack of repair of deaminated cytosine residues in DNA [9].

Other interactions of malM


  1. malM, a new gene of the maltose regulon in Escherichia coli K12. II. Mutations affecting the signal peptide of the MalM protein. Rousset, J.P., Gilson, E., Hofnung, M. J. Mol. Biol. (1986) [Pubmed]
  2. Identification of base mismatches recognized by the heteroduplex-DNA-repair system of Streptococcus pneumoniae. Lacks, S.A., Dunn, J.J., Greenberg, B. Cell (1982) [Pubmed]
  3. Completion of the nucleotide sequence of the 'maltose B' region in Salmonella typhimurium: the high conservation of the malM gene suggests a selected physiological role for its product. Schneider, E., Francoz, E., Dassa, E. Biochim. Biophys. Acta (1992) [Pubmed]
  4. Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12. Clément, J.M., Hofnung, M. Cell (1981) [Pubmed]
  5. MalR-mediated regulation of the Streptococcus pneumoniae malMP operon at promoter PM. Influence of a proximal divergent promoter region and competition between MalR and RNA polymerase proteins. Nieto, C., Puyet, A., Espinosa, M. J. Biol. Chem. (2001) [Pubmed]
  6. The maltose/maltodextrin regulon of Streptococcus pneumoniae. Differential promoter regulation by the transcriptional repressor MalR. Nieto, C., Espinosa, M., Puyet, A. J. Biol. Chem. (1997) [Pubmed]
  7. malM, a new gene of the maltose regulon in Escherichia coli K12. I. malM is the last gene of the malK-lamB operon and encodes a periplasmic protein. Gilson, E., Rousset, J.P., Charbit, A., Perrin, D., Hofnung, M. J. Mol. Biol. (1986) [Pubmed]
  8. Ectopic integration of chromosomal genes in Streptococcus pneumoniae. Mannarelli, B.M., Lacks, S.A. J. Bacteriol. (1984) [Pubmed]
  9. Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae. Chen, J.D., Lacks, S.A. J. Bacteriol. (1991) [Pubmed]
  10. Nucleotide sequence of DNA controlling expression of genes for maltosaccharide utilization in Streptococcus pneumoniae. Stassi, D.L., Dunn, J.J., Lacks, S.A. Gene (1982) [Pubmed]
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