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Gene Review

HI0561  -  hypothetical protein

Haemophilus influenzae Rd KW20

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Disease relevance of HI0561

  • The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein [1].
  • We show that the protein is exported to the E. coli surface, processed by an endogenous serine-protease activity and released in the culture supernatant [2].
  • We have studied a novel autotransporter serine protease, designated NalP, from Neisseria meningitidis strain H44/76, featuring a lipoprotein motif at the signal sequence cleavage site [3].
  • Recombinant HtrA (rHtrA) was expressed from E. coli, and the purified protein was found to have serine protease activity. rHtrA was found to be very immunogenic and partially protective in both the passive infant rat model of bacteremia and the active chinchilla model of otitis media [4].

High impact information on HI0561


Analytical, diagnostic and therapeutic context of HI0561


  1. The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein. Hendrixson, D.R., St Geme, J.W. Mol. Cell (1998) [Pubmed]
  2. Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity. Serruto, D., Adu-Bobie, J., Scarselli, M., Veggi, D., Pizza, M., Rappuoli, R., Aricò, B. Mol. Microbiol. (2003) [Pubmed]
  3. A Neisserial autotransporter NalP modulating the processing of other autotransporters. van Ulsen, P., van Alphen, L., ten Hove, J., Fransen, F., van der Ley, P., Tommassen, J. Mol. Microbiol. (2003) [Pubmed]
  4. The Haemophilus influenzae HtrA protein is a protective antigen. Loosmore, S.M., Yang, Y.P., Oomen, R., Shortreed, J.M., Coleman, D.C., Klein, M.H. Infect. Immun. (1998) [Pubmed]
  5. EspP, a novel extracellular serine protease of enterohaemorrhagic Escherichia coli O157:H7 cleaves human coagulation factor V. Brunder, W., Schmidt, H., Karch, H. Mol. Microbiol. (1997) [Pubmed]
  6. Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic RNA homopolymers. Simon, S., Vered, M., Rinehart, A., Janoff, A. Exp. Lung Res. (1988) [Pubmed]
  7. Structural determinants of processing and secretion of the Haemophilus influenzae hap protein. Hendrixson, D.R., de la Morena, M.L., Stathopoulos, C., St Geme, J.W. Mol. Microbiol. (1997) [Pubmed]
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