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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ampD  -  N-acetyl-anhydromuranmyl-L-alanine amidase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of ampD


High impact information on ampD

  • In contrast, the ampD mutant accumulates a novel cell wall muropeptide, 1,6-anhydro N-acetylmuramyl-L-alanyl-D-glutamyl-meso-diaminopimelic acid (anhMurNAc-tripeptide), in its cytoplasm [4].
  • Mutations within the structural gene of ampD can lead to AmpC overproduction and increases in beta-lactam MICs in organisms with an inducible ampC [1].
  • However, ampD truncation products and ampD from a partially derepressed P. aeruginosa strain resulted in ceftazidime MICs of >256 microg/ml, indicating a role for these gene modifications in derepressed phenotypes [1].
  • The alternative mechanism involved in the derepressed phenotype of the C. freundii isolate was downregulation of ampD transcription [1].


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