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Chemical Compound Review

Adoxa     (2Z,4S,4aR,5S,5aS,6R,12aS)-2- (amino...

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Disease relevance of Vibravenos


Psychiatry related information on Vibravenos


High impact information on Vibravenos


Chemical compound and disease context of Vibravenos


Biological context of Vibravenos


Anatomical context of Vibravenos


Associations of Vibravenos with other chemical compounds


Gene context of Vibravenos

  • Specifically, loss of one p53 allele dramatically facilitates the progression of mammary tumors to a Wnt1-independent state both by impairing the regression of primary tumors following doxycycline withdrawal and by promoting the recurrence of fully regressed tumors in the absence of doxycycline [28].
  • Elastase-induced aneurysmal degeneration was suppressed by treatment with a nonselective MMP inhibitor (doxycycline) and by targeted gene disruption of MMP-9, but not by isolated deficiency of MMP-12 [29].
  • TFF1 effects were investigated in IEC18, HCT116, and AGS gastrointestinal cells treated with recombinant human TFF1, and in stably transfected HCT116 cells synthesizing constitutive or doxycycline-induced human TFF1 [30].
  • Induction of NFIen in a subset of type II cells inhibited SP-C gene expression without affecting expression of TTF-1 in doxycycline-treated double-transgenic mice [31].
  • C. glabrata cells containing the CBF1 gene under the influence of a shutdown promoter (tetO-ScHOP) arrested their growth after 5 h of cultivation in the presence of the reactive drug doxycycline [32].

Analytical, diagnostic and therapeutic context of Vibravenos


  1. Single-dose doxycycline for the prevention of Lyme disease. Leenders, A.C. N. Engl. J. Med. (2001) [Pubmed]
  2. Prophylaxis against leptospirosis with doxycycline. Krick, W.K. N. Engl. J. Med. (1984) [Pubmed]
  3. Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya. Sack, D.A., Kaminsky, D.C., Sack, R.B., Itotia, J.N., Arthur, R.R., Kapikian, A.Z., Orskov, F., Orskov, I. N. Engl. J. Med. (1978) [Pubmed]
  4. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. Nadelman, R.B., Nowakowski, J., Fish, D., Falco, R.C., Freeman, K., McKenna, D., Welch, P., Marcus, R., Agüero-Rosenfeld, M.E., Dennis, D.T., Wormser, G.P. N. Engl. J. Med. (2001) [Pubmed]
  5. Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Davies, J.E., Wang, L., Garcia-Oroz, L., Cook, L.J., Vacher, C., O'Donovan, D.G., Rubinsztein, D.C. Nat. Med. (2005) [Pubmed]
  6. Minocycline and doxycycline are not beneficial in a model of Huntington's disease. Smith, D.L., Woodman, B., Mahal, A., Sathasivam, K., Ghazi-Noori, S., Lowden, P.A., Bates, G.P., Hockly, E. Ann. Neurol. (2003) [Pubmed]
  7. CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus. Bahi, A., Boyer, F., Kafri, T., Dreyer, J.L. Eur. J. Neurosci. (2004) [Pubmed]
  8. Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men. Lister, P.J., Balechandran, T., Ridgway, G.L., Robinson, A.J. J. Antimicrob. Chemother. (1993) [Pubmed]
  9. Urinary urgency and frequency, and chronic urethral and/or pelvic pain in females. Can doxycycline help? Burkhard, F.C., Blick, N., Hochreiter, W.W., Studer, U.E. J. Urol. (2004) [Pubmed]
  10. A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease. Loeb, M.B., Molloy, D.W., Smieja, M., Standish, T., Goldsmith, C.H., Mahony, J., Smith, S., Borrie, M., Decoteau, E., Davidson, W., McDougall, A., Gnarpe, J., O'DONNell, M., Chernesky, M. Journal of the American Geriatrics Society. (2004) [Pubmed]
  11. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Hochedlinger, K., Yamada, Y., Beard, C., Jaenisch, R. Cell (2005) [Pubmed]
  12. Essential role for oncogenic Ras in tumour maintenance. Chin, L., Tam, A., Pomerantz, J., Wong, M., Holash, J., Bardeesy, N., Shen, Q., O'Hagan, R., Pantginis, J., Zhou, H., Horner, J.W., Cordon-Cardo, C., Yancopoulos, G.D., DePinho, R.A. Nature (1999) [Pubmed]
  13. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Bohl, D., Naffakh, N., Heard, J.M. Nat. Med. (1997) [Pubmed]
  14. Transcriptional activation by tetracyclines in mammalian cells. Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., Bujard, H. Science (1995) [Pubmed]
  15. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. Dattwyler, R.J., Luft, B.J., Kunkel, M.J., Finkel, M.F., Wormser, G.P., Rush, T.J., Grunwaldt, E., Agger, W.A., Franklin, M., Oswald, D., Cockey, L., Maladorno, D. N. Engl. J. Med. (1997) [Pubmed]
  16. Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection. Hooton, T.M., Rogers, M.E., Medina, T.G., Kuwamura, L.E., Ewers, C., Roberts, P.L., Stamm, W.E. JAMA (1990) [Pubmed]
  17. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. Kitani, A., Fuss, I., Nakamura, K., Kumaki, F., Usui, T., Strober, W. J. Exp. Med. (2003) [Pubmed]
  18. Why treatment centres failed to prevent cholera deaths among Rwandan refugees in Goma, Zaire. Siddique, A.K., Salam, A., Islam, M.S., Akram, K., Majumdar, R.N., Zaman, K., Fronczak, N., Laston, S. Lancet (1995) [Pubmed]
  19. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Politi, K., Zakowski, M.F., Fan, P.D., Schonfeld, E.A., Pao, W., Varmus, H.E. Genes Dev. (2006) [Pubmed]
  20. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Fisher, G.H., Wellen, S.L., Klimstra, D., Lenczowski, J.M., Tichelaar, J.W., Lizak, M.J., Whitsett, J.A., Koretsky, A., Varmus, H.E. Genes Dev. (2001) [Pubmed]
  21. Influence of subsalicylate bismuth on absorption of doxycycline. Ericsson, C.D., Feldman, S., Pickering, L.K., Cleary, T.G. JAMA (1982) [Pubmed]
  22. Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. Pao, W., Klimstra, D.S., Fisher, G.H., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. Inducible and reversible gene expression with the rtTA system for the study of memory. Mansuy, I.M., Winder, D.G., Moallem, T.M., Osman, M., Mayford, M., Hawkins, R.D., Kandel, E.R. Neuron (1998) [Pubmed]
  24. Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. Legname, G., Seddon, B., Lovatt, M., Tomlinson, P., Sarner, N., Tolaini, M., Williams, K., Norton, T., Kioussis, D., Zamoyska, R. Immunity (2000) [Pubmed]
  25. Update on prevention of malaria for travelers. Lobel, H.O., Kozarsky, P.E. JAMA (1997) [Pubmed]
  26. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Amin, A.R., Attur, M.G., Thakker, G.D., Patel, P.D., Vyas, P.R., Patel, R.N., Patel, I.R., Abramson, S.B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  27. Controlling transgene expression to study Xenopus laevis metamorphosis. Das, B., Brown, D.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  28. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Gunther, E.J., Moody, S.E., Belka, G.K., Hahn, K.T., Innocent, N., Dugan, K.D., Cardiff, R.D., Chodosh, L.A. Genes Dev. (2003) [Pubmed]
  29. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. Pyo, R., Lee, J.K., Shipley, J.M., Curci, J.A., Mao, D., Ziporin, S.J., Ennis, T.L., Shapiro, S.D., Senior, R.M., Thompson, R.W. J. Clin. Invest. (2000) [Pubmed]
  30. The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis. Bossenmeyer-Pourié, C., Kannan, R., Ribieras, S., Wendling, C., Stoll, I., Thim, L., Tomasetto, C., Rio, M.C. J. Cell Biol. (2002) [Pubmed]
  31. Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Bachurski, C.J., Yang, G.H., Currier, T.A., Gronostajski, R.M., Hong, D. Mol. Cell. Biol. (2003) [Pubmed]
  32. Multifunctional centromere binding factor 1 is essential for chromosome segregation in the human pathogenic yeast Candida glabrata. Stoyan, T., Gloeckner, G., Diekmann, S., Carbon, J. Mol. Cell. Biol. (2001) [Pubmed]
  33. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. Takafuji, E.T., Kirkpatrick, J.W., Miller, R.N., Karwacki, J.J., Kelley, P.W., Gray, M.R., McNeill, K.M., Timboe, H.L., Kane, R.E., Sanchez, J.L. N. Engl. J. Med. (1984) [Pubmed]
  34. Long-term eradication of Chlamydia trachomatis genital infection after antimicrobial therapy. Evidence against persistent infection. Workowski, K.A., Lampe, M.F., Wong, K.G., Watts, M.B., Stamm, W.E. JAMA (1993) [Pubmed]
  35. Doxycycline treatment and human infertility. Harrison, R.F., de Louvois, J., Blades, M., Hurley, R. Lancet (1975) [Pubmed]
  36. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Watt, G., Chouriyagune, C., Ruangweerayud, R., Watcharapichat, P., Phulsuksombati, D., Jongsakul, K., Teja-Isavadharm, P., Bhodhidatta, D., Corcoran, K.D., Dasch, G.A., Strickman, D. Lancet (1996) [Pubmed]
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