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Gene Review

MATR3  -  matrin 3

Homo sapiens

Synonyms: ALS21, KIAA0723, MGC9105, MPD2, Matrin-3, ...
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Disease relevance of MATR3


High impact information on MATR3


Biological context of MATR3


Associations of MATR3 with chemical compounds

  • Human NP220 (hNP220) is a novel DNA-binding nuclear protein, which has an arginine/serine-rich motif and polypyrimidine tract-binding motif, and NP220s and matrin 3 are thought to form a novel family of nuclear proteins [7].

Other interactions of MATR3


  1. Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. Warder, D.E., Keherly, M.J. J. Biomed. Sci. (2003) [Pubmed]
  2. Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain. Bernert, G., Fountoulakis, M., Lubec, G. Proteomics (2002) [Pubmed]
  3. The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs. Zhang, Z., Carmichael, G.G. Cell (2001) [Pubmed]
  4. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. Inagaki, H., Matsushima, Y., Nakamura, K., Ohshima, M., Kadowaki, T., Kitagawa, Y. J. Biol. Chem. (1996) [Pubmed]
  5. Bipartite nuclear localization signal of matrin 3 is essential for vertebrate cells. Hisada-Ishii, S., Ebihara, M., Kobayashi, N., Kitagawa, Y. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  6. Soy extract has different effects compared with the isolated isoflavones on the proteome of homocysteine-stressed endothelial cells. Fuchs, D., Dirscherl, B., Schroot, J.H., Daniel, H., Wenzel, U. Molecular nutrition & food research. (2006) [Pubmed]
  7. Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3. Okumara, K., Nogami, M., Matsushima, Y., Matsumura, K., Nakamura, K., Taguchi, H., Kitagawa, Y. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
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