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Gene Review

CIZ1  -  CDKN1A interacting zinc finger protein 1

Homo sapiens

Synonyms: CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, LSFR1, NP94, Nuclear protein NP94, ...
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Disease relevance of CIZ1

  • We have isolated and characterized another member of the matrin 3 family, designated NP94, from a medulloblastoma [1].
  • Despite the emerging significance of Ciz1 in the biology of breast cancer cells, regulation of endogenous Ciz1 in hormone-responsive cancer cells remains unknown [2].
  • In addition, we found that Ciz1 overexpression confers estrogen hypersensitivity to breast cancer cells and promotes the growth rate, anchorage independency, and tumorigenic properties of breast cancer cells [2].

High impact information on CIZ1


Biological context of CIZ1


Associations of CIZ1 with chemical compounds


Regulatory relationships of CIZ1


Other interactions of CIZ1

  • When Ciz1 and p21(Cip1/Waf1) were individually overexpressed in U2-OS cells, they mostly localized in the nucleus [5].

Analytical, diagnostic and therapeutic context of CIZ1

  • From the analysis of the retrieved SAAB sequences and verification using electrophoretic mobility shift assays, we formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 [1].
  • Analysis of green fluorescent protein-tagged fragments indicates that nuclear immobilization of Ciz1 is mediated by sequences in its C-terminal third, encoded within amino acids 708-830 [4].


  1. Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. Warder, D.E., Keherly, M.J. J. Biomed. Sci. (2003) [Pubmed]
  2. Ciz1, a Novel DNA-Binding Coactivator of the Estrogen Receptor {alpha}, Confers Hypersensitivity to Estrogen Action. den Hollander, P., Rayala, S.K., Coverley, D., Kumar, R. Cancer Res. (2006) [Pubmed]
  3. Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells. den Hollander, P., Kumar, R. Cancer Res. (2006) [Pubmed]
  4. C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix. Ainscough, J.F., Rahman, F.A., Sercombe, H., Sedo, A., Gerlach, B., Coverley, D. J. Cell. Sci. (2007) [Pubmed]
  5. Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1. Mitsui, K., Matsumoto, A., Ohtsuka, S., Ohtsubo, M., Yoshimura, A. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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