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KIF14  -  kinesin family member 14

Homo sapiens

Synonyms: KIAA0042, Kinesin-like protein KIF14
 
 
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Disease relevance of KIF14

 

High impact information on KIF14

 

Biological context of KIF14

  • KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers [1].
  • Cells at later stages of mitosis were characterized by the concentration of KIF14 at the midbody [4].
  • Furthermore, the link we observed between siRNA efficacy and phenotypic outcome indicates that distinct stages during cell cycle progression are disrupted by the differential modulation of KIF14 expression [4].
  • Time-lapse microscopy revealed that strong RNA interference (RNAi)-mediated silencing of KIF14 induced cytokinesis failure, causing several rounds of endoreduplication and resulting in multinucleated cells [4].
  • Additionally, less efficacious KIF14-specific short interfering RNAs (siRNAs) induced multiple phenotypes, all of which resulted in acute apoptosis [4].
 

Anatomical context of KIF14

  • KIF14 expression correlated positively with Ki-67 mRNA level (Spearman r = 0.692, p = 0.000001), fraction of positive nodes (r = 0.227, p = 0.024) and percent invasive cells (r = 0.360, p = 0.0002), and negatively with percent fatty stroma (r = -0.258, p = 0.010) and percent normal epithelium (r = -0.291, p = 0.003) [5].
 

Other interactions of KIF14

  • Of these, only KIF14, a putative chromokinesin, was overexpressed in various cancers by real-time RT-PCR [1].
  • Measured by real-time RT-PCR, KIF14 was overexpressed 10-fold on average in tumors relative to normals (t test p = 0.000054); expression increased with grade (ANOVA p = 0.000006) [5].
 

Analytical, diagnostic and therapeutic context of KIF14

References

  1. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Corson, T.W., Huang, A., Tsao, M.S., Gallie, B.L. Oncogene (2005) [Pubmed]
  2. KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer. Corson, T.W., Zhu, C.Q., Lau, S.K., Shepherd, F.A., Tsao, M.S., Gallie, B.L. Clin. Cancer Res. (2007) [Pubmed]
  3. KIF14 and citron kinase act together to promote efficient cytokinesis. Gruneberg, U., Neef, R., Li, X., Chan, E.H., Chalamalasetty, R.B., Nigg, E.A., Barr, F.A. J. Cell Biol. (2006) [Pubmed]
  4. RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure. Carleton, M., Mao, M., Biery, M., Warrener, P., Kim, S., Buser, C., Marshall, C.G., Fernandes, C., Annis, J., Linsley, P.S. Mol. Cell. Biol. (2006) [Pubmed]
  5. KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Corson, T.W., Gallie, B.L. Int. J. Cancer (2006) [Pubmed]
  6. Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. Bowles, E., Corson, T.W., Bayani, J., Squire, J.A., Wong, N., Lai, P.B., Gallie, B.L. Genes Chromosomes Cancer (2007) [Pubmed]
 
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