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Gene Review

KIF4A  -  kinesin family member 4A

Homo sapiens

Synonyms: Chromokinesin-A, Chromosome-associated kinesin KIF4A, FLJ12530, FLJ12655, FLJ14204, ...
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Disease relevance of KIF4A


High impact information on KIF4A

  • When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival [3].
  • Here, we report that the activity-dependent prevention of apoptosis in juvenile neurons is regulated by kinesin superfamily protein 4 (KIF4), a microtubule-based molecular motor [3].
  • After dissociation from PARP-1, KIF4 enters into the cytoplasm from the nucleus and moves to the distal part of neurites in a microtubule-dependent manner [3].
  • The C-terminal domain of KIF4 is a module that suppresses the activity of poly (ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme known to maintain cell homeostasis by repairing DNA and serving as a transcriptional regulator [3].
  • Inactivation of the chromokinesin hKid, by RNAi or antibody microinjection, prevented the formation of stable bipolar spindles and the 'metaphase-like' alignment of chromosomes in cells expressing stable cyclinB1 [4].

Biological context of KIF4A


Anatomical context of KIF4A

  • KIF4 protein has the property of nucleotide-dependent binding to microtubules, microtubule-activated ATPase activity, and microtubule plus-end-directed motility [8].
  • A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally [8].
  • Immunocytochemical studies revealed that KIF4 colocalized with membranous organelles both in growth cones of differentiated neurons and in the cytoplasm of cultured fibroblasts [8].
  • As an initial step to understand the function(s) of human KIF4, its subcellular localization in HeLa cells was examined by using immunocytochemical and subcellular fractionation methods, and it was found that most KIF4 is localized in the nucleus [10].
  • Since murine KIF4 is known to transport cytoplasmic vesicles, dominant nuclear localization of the human counterpart was somewhat surprising [10].

Physical interactions of KIF4A

  • Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation [11].

Co-localisations of KIF4A


Other interactions of KIF4A


Analytical, diagnostic and therapeutic context of KIF4A


  1. Cellular motor protein KIF-4 associates with retroviral Gag. Tang, Y., Winkler, U., Freed, E.O., Torrey, T.A., Kim, W., Li, H., Goff, S.P., Morse, H.C. J. Virol. (1999) [Pubmed]
  2. Increased chromokinesin immunoreactivity in retinoblastoma cells. Yan, R.T., Wang, S.Z. Gene (1997) [Pubmed]
  3. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Midorikawa, R., Takei, Y., Hirokawa, N. Cell (2006) [Pubmed]
  4. Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells. Wolf, F., Wandke, C., Isenberg, N., Geley, S. EMBO J. (2006) [Pubmed]
  5. Human chromokinesin KIF4A functions in chromosome condensation and segregation. Mazumdar, M., Sundareshan, S., Misteli, T. J. Cell Biol. (2004) [Pubmed]
  6. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. Ha, M.J., Yoon, J., Moon, E., Lee, Y.M., Kim, H.J., Kim, W. Cytogenet. Cell Genet. (2000) [Pubmed]
  7. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Lee, Y.M., Kim, W. Biochem. J. (2003) [Pubmed]
  8. A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. Sekine, Y., Okada, Y., Noda, Y., Kondo, S., Aizawa, H., Takemura, R., Hirokawa, N. J. Cell Biol. (1994) [Pubmed]
  9. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Zhu, C., Jiang, W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. Lee, Y.M., Lee, S., Lee, E., Shin, H., Hahn, H., Choi, W., Kim, W. Biochem. J. (2001) [Pubmed]
  11. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. Kurasawa, Y., Earnshaw, W.C., Mochizuki, Y., Dohmae, N., Todokoro, K. EMBO J. (2004) [Pubmed]
  12. Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Geiman, T.M., Sankpal, U.T., Robertson, A.K., Chen, Y., Mazumdar, M., Heale, J.T., Schmiesing, J.A., Kim, W., Yokomori, K., Zhao, Y., Robertson, K.D. Nucleic Acids Res. (2004) [Pubmed]
  13. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Corson, T.W., Huang, A., Tsao, M.S., Gallie, B.L. Oncogene (2005) [Pubmed]
  14. Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation. Trieselmann, N., Armstrong, S., Rauw, J., Wilde, A. J. Cell. Sci. (2003) [Pubmed]
  15. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. Shiroguchi, K., Ohsugi, M., Edamatsu, M., Yamamoto, T., Toyoshima, Y.Y. J. Biol. Chem. (2003) [Pubmed]
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