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MeSH Review

Heavy Chain Disease

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High impact information on Heavy Chain Disease


Chemical compound and disease context of Heavy Chain Disease


Biological context of Heavy Chain Disease


Anatomical context of Heavy Chain Disease

  • A series of mouse myeloma cell lines producing mutant gamma 2b immunoglobin heavy chains, which resemble heavy chain disease proteins, were analyzed for messenger RNA abundance as a function of mRNA alterations [10].

Gene context of Heavy Chain Disease


Analytical, diagnostic and therapeutic context of Heavy Chain Disease


  1. Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone. Lyons, R.M., Chaplin, H., Tillack, T.W., Majerus, P.W. Blood (1975) [Pubmed]
  2. Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. Corcos, D., Dunda, O., Butor, C., Cesbron, J.Y., Lorès, P., Bucchini, D., Jami, J. Curr. Biol. (1995) [Pubmed]
  3. Spontaneous somatic mutations. Structural studies on mutant immunoglobulins. Adetugbo, K. J. Biol. Chem. (1978) [Pubmed]
  4. Crystals of the human heavy chain disease protein Riv and human Fc fragment are isomorphous: further evidence for conformational flexibility in the hinge region of immunoglobulins. Mariuzza, R.A., Poljak, R.J., Mihaesco, C., Mihaesco, E. J. Mol. Biol. (1983) [Pubmed]
  5. Alpha heavy chain disease alpha mRNA contain nucleotide sequences of unknown origins. Fakhfakh, F., Dellagi, K., Ayadi, H., Bouguerra, A., Fourati, R., Ben Ayed, F., Brouet, J.C., Tsapis, A. Eur. J. Immunol. (1992) [Pubmed]
  6. Fludarabine in lymphoproliferative disorders: the Royal Marsden Hospital experience. O'Brien, M.E., Matutes, E., Cunningham, D., Hill, M., Emmett, E., Ellis, P.A., Milan, S., Hickish, T., Mercieca, J., Catovsky, D. Leuk. Lymphoma (1994) [Pubmed]
  7. Gamma heavy chain disease with an unusually benign course. Van Bergeijk, L., Biewenga, J., Langenhuijsen, M.M. Clinical and laboratory haematology. (1980) [Pubmed]
  8. Immunobiology and pathogenesis of alpha chain disease. Seligmann, M. Ciba Found. Symp. (1977) [Pubmed]
  9. Alpha heavy chain disease of patient MAL: structure of the non-functional rearranged alpha gene translocated on chromosome 9. Pellet, P., Tsapis, A., Brouet, J.C. Eur. J. Immunol. (1990) [Pubmed]
  10. Differential mRNA stabilities affect mRNA levels in mutant mouse myeloma cells. Genovese, C., Harrold, S., Milcarek, C. Somat. Cell Mol. Genet. (1991) [Pubmed]
  11. Genomic alterations in a case of alpha heavy chain disease leading to the generation of composite exons from the JH region. Bentaboulet, M., Mihaesco, E., Gendron, M.C., Brouet, J.C., Tsapis, A. Eur. J. Immunol. (1989) [Pubmed]
  12. Gamma heavy chain disease and rheumatoid arthritis. Dickson, J.R., Harth, M., Bell, D.A., Komar, R., Chodirker, W.B. Semin. Arthritis Rheum. (1989) [Pubmed]
  13. A case of mu heavy-chain disease associated with hyperglobulinemia, anemia, and a positive Coombs test. Witzens, M., Egerer, G., Stahl, D., Werle, E., Goldschmidt, H., Haas, R. Ann. Hematol. (1998) [Pubmed]
  14. N-ras oncogene activation in a patient with gamma heavy chain disease. Moskovits, T., Jacobson, D.R., Buxbaum, J. Am. J. Hematol. (1992) [Pubmed]
  15. Detection and preparation of immunoglobulin (Ig) mu chain protein in sera of patients with heavy chain diseases (HCD). Wetter, O., Drosdziok, W., Müller, B. Klin. Wochenschr. (1975) [Pubmed]
  16. Two-dimensional immunolectrophoresis as a diagnostic tool for heavy chain disease. Dammacco, F., Antonaci, S., Miglietta, A. Bollettino dell'Istituto sieroterapico milanese. (1975) [Pubmed]
  17. A comparison of several immunochemical approaches for the screening of alpha chain disease. Orr, K.B. Diagnostic immunology. (1983) [Pubmed]
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