Disease relevance of Burning Mouth Syndrome

• We report 12 cases of contact sensitivity to the flavouring agents menthol and peppermint oil in patients presenting with intra-oral symptoms in association with burning mouth syndrome, recurrent oral ulceration or a lichenoid reaction [1].
• The experimental group consisted of biopsy proven OLP subjects (n = 41), negative control consisted of apparently healthy general Out Patient Department (OPD) patients (n = 73) and positive controls were patients with burning mouth syndrome, atypical facial pain and myofacial pain dysfunction syndrome (n = 36) [2].

High impact information on Burning Mouth Syndrome

• Striatal dopamine D1 and D2 receptors in burning mouth syndrome [3].
• Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study [4].
• Effectiveness of gabapentin for treatment of burning mouth syndrome [5].
• Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy [6].
• OBJECTIVE: To report the first published case of clonazepam-induced burning mouth syndrome (BMS) [7].

Chemical compound and disease context of Burning Mouth Syndrome

• RESULTS AND CONCLUSION: Following treatment with alpha-lipoic acid, there was a significant symptomatic improvement, compared with placebo, with the majority showing at least some improvement after 2 months, thus supporting the hypothesis that burning mouth syndrome is a neuropathy [6].
• Burning mouth syndrome due to nicotinic acid esters and sorbic acid [8].
• No statistically significant differences in serum levels of iron, folic acid, calcium and magnesium were found between patients with burning mouth syndrome and controls [9].
• OBJECTIVE: The purpose of this study was to evaluate the efficacy of the topical use of benzydamine hydrochloride 0.15% oral mouthwashes in the control of burning mouth syndrome symptoms [10].
• CONCLUSIONS: The clinical application of benzydamine hydrochloride oral rinses in the treatment of patients with burning mouth syndrome did not demonstrate significative efficacy in comparison with use of a placebo solution [10].

Gene context of Burning Mouth Syndrome

• Statistically significant lowered vitamin B12 levels were found in patients with burning mouth syndrome [9].
• Statistical analysis showed no significant differences in the level of tumour markers CEA, CA 19-9, AFP, CYFRA 21-1 in patients with burning mouth syndrome when compared to the healthy controls [11].
• SUMMARY Burning mouth syndrome is an oral dysaesthesia presenting as a burning sensation of the tongue and less frequently other oral and peri-oral sites [12].
• BACKGROUND: Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS) [13].
• In 23 patients with burning mouth syndrome as well as in 20 age, sex, and race matched healthy controls levels of tumour markers-CEA, CA 19-9, AFP, and CYFRA 21-1-were determined from sera [11].

Analytical, diagnostic and therapeutic context of Burning Mouth Syndrome

• Capsaicin in burning mouth syndrome: titration strategies [14].

References