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Chemical Compound Review

thioctic acid     5-[(3R)-dithiolan-3- yl]pentanoic acid

Synonyms: liponate, Biletan, Thioctsan, Thiogamma, lipoate, ...
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Chemical compound and disease context of Thioctacid


Biological context of Thioctacid


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Gene context of Thioctacid


Analytical, diagnostic and therapeutic context of Thioctacid


  1. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Kim, M.S., Park, J.Y., Namkoong, C., Jang, P.G., Ryu, J.W., Song, H.S., Yun, J.Y., Namgoong, I.S., Ha, J., Park, I.S., Lee, I.K., Viollet, B., Youn, J.H., Lee, H.K., Lee, K.U. Nat. Med. (2004) [Pubmed]
  2. alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. Ha, H., Lee, J.H., Kim, H.N., Kim, H.M., Kwak, H.B., Lee, S., Kim, H.H., Lee, Z.H. J. Immunol. (2006) [Pubmed]
  3. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Kowluru, R.A., Odenbach, S. Diabetes (2004) [Pubmed]
  4. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Ziegler, D., Gries, F.A. Diabetes (1997) [Pubmed]
  5. ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential. Mathews, C.E., Bagley, R., Leiter, E.H. Diabetes (2004) [Pubmed]
  6. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Müller, M., Wahl, P., Ziegler, R., Nawroth, P.P. Diabetes (1997) [Pubmed]
  7. Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease. Mohmmad Abdul, H., Butterfield, D.A. Free Radic. Biol. Med. (2007) [Pubmed]
  8. The effects of aging and oxidative stress on learning behavior in C. elegans. Murakami, S., Murakami, H. Neurobiol. Aging (2005) [Pubmed]
  9. Cell-density-dependent regulation of neural precursor cell function. Limoli, C.L., Rola, R., Giedzinski, E., Mantha, S., Huang, T.T., Fike, J.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. Arlt, V.M., Stiborova, M., Hewer, A., Schmeiser, H.H., Phillips, D.H. Cancer Res. (2003) [Pubmed]
  11. Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. Sen, C.K., Sashwati, R., Packer, L. Cell Death Differ. (1999) [Pubmed]
  12. Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration. Sriram, K., Shankar, S.K., Boyd, M.R., Ravindranath, V. J. Neurosci. (1998) [Pubmed]
  13. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation. Lykkesfeldt, J., Hagen, T.M., Vinarsky, V., Ames, B.N. FASEB J. (1998) [Pubmed]
  14. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. Melhem, M.F., Craven, P.A., Derubertis, F.R. J. Am. Soc. Nephrol. (2001) [Pubmed]
  15. Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. Koya, D., Hayashi, K., Kitada, M., Kashiwagi, A., Kikkawa, R., Haneda, M. J. Am. Soc. Nephrol. (2003) [Pubmed]
  16. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Borcea, V., Nourooz-Zadeh, J., Wolff, S.P., Klevesath, M., Hofmann, M., Urich, H., Wahl, P., Ziegler, R., Tritschler, H., Halliwell, B., Nawroth, P.P. Free Radic. Biol. Med. (1999) [Pubmed]
  17. In vitro effects of vitamin C, thioctic acid and dihydrolipoic acid on the cytotoxicity of post-ethanol serum. Wickramasinghe, S.N., Hasan, R. Biochem. Pharmacol. (1992) [Pubmed]
  18. An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Sasaki, A., Oshima, Y., Fujimura, A. Exp. Hematol. (2007) [Pubmed]
  19. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Low, P.A., Nickander, K.K., Tritschler, H.J. Diabetes (1997) [Pubmed]
  20. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Maddux, B.A., See, W., Lawrence, J.C., Goldfine, A.L., Goldfine, I.D., Evans, J.L. Diabetes (2001) [Pubmed]
  21. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., Klip, A. Diabetes (2001) [Pubmed]
  22. The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Jacob, S., Streeper, R.S., Fogt, D.L., Hokama, J.Y., Tritschler, H.J., Dietze, G.J., Henriksen, E.J. Diabetes (1996) [Pubmed]
  23. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Estrada, D.E., Ewart, H.S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., Klip, A. Diabetes (1996) [Pubmed]
  24. Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways. Cho, K.J., Moon, H.E., Moini, H., Packer, L., Yoon, D.Y., Chung, A.S. J. Biol. Chem. (2003) [Pubmed]
  25. Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Coppey, L.J., Gellett, J.S., Davidson, E.P., Dunlap, J.A., Lund, D.D., Yorek, M.A. Diabetes (2001) [Pubmed]
  26. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Abiko, T., Abiko, A., Clermont, A.C., Shoelson, B., Horio, N., Takahashi, J., Adamis, A.P., King, G.L., Bursell, S.E. Diabetes (2003) [Pubmed]
  27. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. Melhem, M.F., Craven, P.A., Liachenko, J., DeRubertis, F.R. J. Am. Soc. Nephrol. (2002) [Pubmed]
  28. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Hounsom, L., Horrobin, D.F., Tritschler, H., Corder, R., Tomlinson, D.R. Diabetologia (1998) [Pubmed]
  29. N-acetylcysteine decreases angiotensin II receptor binding in vascular smooth muscle cells. Ullian, M.E., Gelasco, A.K., Fitzgibbon, W.R., Beck, C.N., Morinelli, T.A. J. Am. Soc. Nephrol. (2005) [Pubmed]
  30. alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Mackenzie, G.G., Zago, M.P., Erlejman, A.G., Aimo, L., Keen, C.L., Oteiza, P.I. Free Radic. Res. (2006) [Pubmed]
  31. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase. Korotchkina, L.G., Sidhu, S., Patel, M.S. Free Radic. Res. (2004) [Pubmed]
  32. Radiation-induced cyclooxygenase 2 up-regulation is dependent on redox status in prostate cancer cells. Li, L., Steinauer, K.K., Dirks, A.J., Husbeck, B., Gibbs, I., Knox, S.J. Radiat. Res. (2003) [Pubmed]
  33. Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. Bitar, M.S., Wahid, S., Pilcher, C.W., Al-Saleh, E., Al-Mulla, F. Horm. Metab. Res. (2004) [Pubmed]
  34. Regulation of mitochondrial transcription factor A expression by high glucose. Choi, Y.S., Lee, K.U., Pak, Y.K. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  35. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Hofmann, M.A., Schiekofer, S., Isermann, B., Kanitz, M., Henkels, M., Joswig, M., Treusch, A., Morcos, M., Weiss, T., Borcea, V., Abdel Khalek, A.K., Amiral, J., Tritschler, H., Ritz, E., Wahl, P., Ziegler, R., Bierhaus, A., Nawroth, P.P. Diabetologia (1999) [Pubmed]
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