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MeSH Review

Facial Pain

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Disease relevance of Facial Pain


Psychiatry related information on Facial Pain


High impact information on Facial Pain


Chemical compound and disease context of Facial Pain


Biological context of Facial Pain

  • A 37-yr-old man with a 60-mm invasive tumor and a serum PRL level of 13,969 +/- 332 ng/ml (mean +/- SD) responded to BRC therapy with rapid disappearance of visual field defect, headache, and facial pain as well as decrease in serum PRL to 5,103 +/- 1,446 ng/ml [10].
  • Acupuncture TMD and facial pain [18].

Anatomical context of Facial Pain


Gene context of Facial Pain

  • Altered dopamine D2 receptor binding in atypical facial pain [16].
  • Dr. David Jones refutes the Melkonians' support of the AACP application for craniofacial pain specialty [24].
  • In addition, proband descriptors of facial pain severity or disability did not significantly predict the likelihood of having a first degree relative with one or more TMD-related symptoms [25].
  • Dates of initial onsets of myofascial face pain and MDD in patient probands were obtained from interviews and records [26].
  • In two atypical facial pain studies the combined odds ratio for benefit was 4.1 (2.3-7.5), with a NNT of 2.8 (2-4.7) [27].

Analytical, diagnostic and therapeutic context of Facial Pain


  1. Changes of biological rhythms in primary headache syndromes. Ferrari, E., Canepari, C., Bossolo, P.A., Vailati, A., Martignoni, E., Micieli, G., Nappi, G. Cephalalgia : an international journal of headache. (1983) [Pubmed]
  2. Primary yawning headache. Jacome, D.E. Cephalalgia : an international journal of headache. (2001) [Pubmed]
  3. Therapeutic uses of non-steroidal anti-inflammatory drugs in dentistry. Dionne, R.A., Berthold, C.W. Crit. Rev. Oral Biol. Med. (2001) [Pubmed]
  4. Percutaneous retrogasserian glycerol rhizolysis in the management of trigeminal neuralgia. Burchiel, K.J. J. Neurosurg. (1988) [Pubmed]
  5. Relationships between depression/somatization and self-reports of pain and disability. Yap, A.U., Chua, E.K., Tan, K.B., Chan, Y.H. Journal of orofacial pain. (2004) [Pubmed]
  6. Case study: worsening Tourette's disorder or withdrawal dystonia? Mennesson, M., Klink, B.A., Fortin, A.H. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  7. Behavior modification and haloperidol in chronic facial pain. Raft, D., Toomey, T., Gregg, J.M. South. Med. J. (1979) [Pubmed]
  8. Metastatic prolactinoma: effect of octreotide, cabergoline, carboplatin and etoposide; immunocytochemical analysis of proto-oncogene expression. Hurel, S.J., Harris, P.E., McNicol, A.M., Foster, S., Kelly, W.F., Baylis, P.H. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  9. Isolated pontine infarctions with prominent ipsilateral midfacial sensory signs. Masjuan, J., Barón, M., Lousa, M., Gobernado, J.M. Stroke (1997) [Pubmed]
  10. Testosterone-related exacerbation of a prolactin-producing macroadenoma: possible role for estrogen. Prior, J.C., Cox, T.A., Fairholm, D., Kostashuk, E., Nugent, R. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  11. Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice. Multon, S., Pardutz, A., Mosen, J., Hua, M.T., Defays, C., Honda, S., Harada, N., Bohotin, C., Franzen, R., Schoenen, J. Pain (2005) [Pubmed]
  12. Local application of the cannabinoid receptor agonist, WIN 55,212-2, to spinal trigeminal nucleus caudalis differentially affects nociceptive and non-nociceptive neurons. Papanastassiou, A.M., Fields, H.L., Meng, I.D. Pain (2004) [Pubmed]
  13. Antihyperalgesic activity of epibatidine in the formalin model of facial pain. Gilbert, S.D., Clark, T.M., Flores, C.M. Pain (2001) [Pubmed]
  14. Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. Mathisen, L.C., Skjelbred, P., Skoglund, L.A., Oye, I. Pain (1995) [Pubmed]
  15. The NMDA antagonist Memantine blocks pain behavior in a rat model of formalin-induced facial pain. Eisenberg, E., Vos, B.P., Strassman, A.M. Pain (1993) [Pubmed]
  16. Altered dopamine D2 receptor binding in atypical facial pain. Hagelberg, N., Forssell, H., Aalto, S., Rinne, J.O., Scheinin, H., Taiminen, T., Någren, K., Eskola, O., Jääskeläinen, S.K. Pain (2003) [Pubmed]
  17. Qualitative light and electron microscope study of glutamate receptors in the caudal spinal trigeminal nucleus of the rat. Tang, F.R., Yeo, J.F., Leong, S.K. J. Dent. Res. (2001) [Pubmed]
  18. Acupuncture TMD and facial pain. Thayer, T. SAAD digest. (2001) [Pubmed]
  19. Erythrocyte catechol-O-methyltransferase activity in facial pain patients. Marbach, J.J., Levitt, M. J. Dent. Res. (1976) [Pubmed]
  20. Atypical facial pain, ectasia of the basilar artery, and baclofen: a case report. Martins, I.P., Ferro, J.M. Headache. (1989) [Pubmed]
  21. MR of osteochondritis dissecans and avascular necrosis of the mandibular condyle. Schellhas, K.P., Wilkes, C.H., Fritts, H.M., Omlie, M.R., Lagrotteria, L.B. AJR. American journal of roentgenology. (1989) [Pubmed]
  22. The foramen lacerum--a route of access to the cranial cavity for malignant tumours below the skull base. Phelps, P.D., Beale, D.J. Clinical radiology. (1992) [Pubmed]
  23. Intranasal Xylocaine: a prognostic aid for pre-operative assessment of facial pain of nasal origin. Landrigan, G.P., Kirkpatrick, D.A. The Journal of otolaryngology. (1992) [Pubmed]
  24. Dr. David Jones refutes the Melkonians' support of the AACP application for craniofacial pain specialty. Jones, D.G. Cranio : the journal of craniomandibular practice. (2002) [Pubmed]
  25. Myofascial TMD does not run in families. Raphael, K.G., Marbach, J.J., Gallagher, R.M., Dohrenwend, B.P. Pain (1999) [Pubmed]
  26. Why is depression comorbid with chronic myofascial face pain? A family study test of alternative hypotheses. Dohrenwend, B.P., Raphael, K.G., Marbach, J.J., Gallagher, R.M. Pain (1999) [Pubmed]
  27. A systematic review of antidepressants in neuropathic pain. McQuay, H.J., Tramèr, M., Nye, B.A., Carroll, D., Wiffen, P.J., Moore, R.A. Pain (1996) [Pubmed]
  28. Persistent idiopathic facial pain following dental implant placement: a case report. Queral-Godoy, E., Vazquez-Delgado, E., Okeson, J.P., Gay-Escoda, C. The International journal of oral & maxillofacial implants. (2006) [Pubmed]
  29. A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain. al Balawi, S., Tariq, M., Feinmann, C. Int. J. Neurosci. (1996) [Pubmed]
  30. Facial pain and temporomandibular disorders: an epidemiological study of the Northern Finland 1966 Birth Cohort. Rauhala, K., Oikarinen, K.S., Järvelin, M.R., Raustia, A.M. Cranio : the journal of craniomandibular practice. (2000) [Pubmed]
  31. Sensorineural hearing loss caused by NSAID-induced aseptic meningitis. Davison, S.P., Marion, M.S. Ear, nose, & throat journal. (1998) [Pubmed]
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