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Chemical Compound Review

Trisamine     2-amino-2- (hydroxymethyl)propane-1,3- diol

Synonyms: Pehanorm, Talatrol, Trisamin, Trizma, Trometamol, ...
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Disease relevance of Trizma


Psychiatry related information on Trizma


High impact information on Trizma


Chemical compound and disease context of Trizma


Biological context of Trizma


Anatomical context of Trizma


Associations of Trizma with other chemical compounds


Gene context of Trizma

  • Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation [23].
  • Tham et al. show that Helicobacter pylori infection lowers the density of immunoreactive somatostatin cells (D-cells) in the antral mucosa and elevates plasma gastrin concentrations [24].
  • Because DNA fragments containing either one or both bubbles migrate in TBM (89 mm Tris base, 89 mm boric acid, and 2 mm MgCl(2)) PAGE even faster than expected from their linear size, interacting regions are expected to belong to the same molecule [25].
  • PATIENTS: Twenty-three patients with severe traumatic brain injury or delayed ischemia after subarachnoid hemorrhage with intracranial hypertension refractory to aggressive treatment, including repeated applications of tromethamine, hypertonic saline solution, barbiturate coma, and decompressive craniectomy [26].
  • A facile chromatography-free route to Kang's intermediate for the synthesis of (+)-lactacystin, a potent proteasome inhibitor, has been developed starting with Brown's asymmetric crotylation of tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate, easily available from 2-amino-2-(hydroxymethyl)propane-1,3-diol (Tris) [27].

Analytical, diagnostic and therapeutic context of Trizma


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  2. Experimental model of single ventricle. Influence of carbon dioxide on pulmonary vascular dynamics. Mora, G.A., Pizarro, C., Jacobs, M.L., Norwood, W.I. Circulation (1994) [Pubmed]
  3. Physiological pH. Effects on posthypoxic proximal tubular injury. Zager, R.A., Schimpf, B.A., Gmur, D.J. Circ. Res. (1993) [Pubmed]
  4. Tromethamine buffer modifies the depressant effect of permissive hypercapnia on myocardial contractility in patients with acute respiratory distress syndrome. Weber, T., Tschernich, H., Sitzwohl, C., Ullrich, R., Germann, P., Zimpfer, M., Sladen, R.N., Huemer, G. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  5. Entry of tromethamine into the cerebrospinal fluid of humans after cerebrovascular events. Nau, R., Desel, H., Lassek, C., Kolenda, H., Prange, H. Clin. Pharmacol. Ther. (1999) [Pubmed]
  6. Oral prophylaxis with fosfomycin trometamol in transurethral prostatectomy and urological maneuvers: literature review and personal experience. Selvaggi, F.P., Battaglia, M., Grossi, F.S., Disabato, G., Cormio, L. Infection (1992) [Pubmed]
  7. Tris buffer attenuates acetylcholine responses in Aplysia neurons. Wilson, W.A., Clark, M.T., Pellmar, T.C. Science (1977) [Pubmed]
  8. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Arispe, N., Rojas, E., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Single-dose fosfomycin trometamol versus 5-day cephalexin regimen for treatment of uncomplicated lower urinary tract infections in women. Elhanan, G., Tabenkin, H., Yahalom, R., Raz, R. Antimicrob. Agents Chemother. (1994) [Pubmed]
  10. Guidelines for the treatment of acidaemia with THAM. Nahas, G.G., Sutin, K.M., Fermon, C., Streat, S., Wiklund, L., Wahlander, S., Yellin, P., Brasch, H., Kanchuger, M., Capan, L., Manne, J., Helwig, H., Gaab, M., Pfenninger, E., Wetterberg, T., Holmdahl, M., Turndorf, H. Drugs (1998) [Pubmed]
  11. Antibiotic prescribing for acute and recurrent cystitis in primary care: a 4 year descriptive study. Galatti, L., Sessa, A., Mazzaglia, G., Pecchioli, S., Rossi, A., Cricelli, C., Schito, G.C., Nicoletti, G., Caputi, A.P. J. Antimicrob. Chemother. (2006) [Pubmed]
  12. Prophylactic and therapeutic carboprost tromethamine bladder irrigation in rats with cyclophosphamide-induced hemorrhagic cystitis. Kranc, D.M., Kim, J., Straus, F., Levine, L.A. J. Urol. (1992) [Pubmed]
  13. Fosfomycin tromethamine. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy as a single-dose oral treatment for acute uncomplicated lower urinary tract infections. Patel, S.S., Balfour, J.A., Bryson, H.M. Drugs (1997) [Pubmed]
  14. 15,15-Ketals of natural prostaglandins and prostaglandin analogues. Synthesis and biological activities. Skuballa, W., Radüchel, B., Loge, O., Elger, W., Vorbrüggen, H. J. Med. Chem. (1978) [Pubmed]
  15. Comparative pharmacokinetics of tromethamine fosfomycin and calcium fosfomycin in young and elderly adults. Borsa, F., Leroy, A., Fillastre, J.P., Godin, M., Moulin, B. Antimicrob. Agents Chemother. (1988) [Pubmed]
  16. Gonadotropin releasing hormone induced luteinizing hormone release after prostaglandin F2alpha in heifers. Convey, E.M., Beal, W.E., Seguin, B.E., Tannen, K.J., Lin, Y.C. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  17. Disruption of the Golgi zone and inhibition of the conversion of proparathyroid hormone to parathyroid hormone in human parathyroid tissue by tris(hydroxymethyl)aminomethane. McGregor, D.H., Chu, L.L., MacGregor, R.R., Cohn, D.V. Am. J. Pathol. (1977) [Pubmed]
  18. Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues. Heaslip, R.J., Grimes, D., Berkenkopf, J.W., Ilsemann, B.A., Sickels, B.D., Weichman, B.M. Eur. J. Pharmacol. (1993) [Pubmed]
  19. Lipids of the retinal pigment epithelium in RCS dystrophic and normal rats. Batey, D.W., Mead, J.F., Eckhert, C.D. Exp. Eye Res. (1986) [Pubmed]
  20. Effects of COR6.6 and COR15am polypeptides encoded by COR (cold-regulated) genes of Arabidopsis thaliana on the freeze-induced fusion and leakage of liposomes. Uemura, M., Gilmour, S.J., Thomashow, M.F., Steponkus, P.L. Plant Physiol. (1996) [Pubmed]
  21. A non-barbital buffer for immunoelectrophoresis and zone electrophoresis in agarose gels. Monthony, J.F., Wallace, E.G., Allen, D.M. Clin. Chem. (1978) [Pubmed]
  22. Feasibility of measuring free and total bilirubin electrochemically in serum. Koch, T.R., Akingbe, O.O. Clin. Chem. (1981) [Pubmed]
  23. Antinociception and the new COX inhibitors: research approaches and clinical perspectives. Herrero, J.F., Romero-Sandoval, E.A., Gaitan, G., Mazario, J. CNS drug reviews. (2003) [Pubmed]
  24. Helicobacter pylori and somatostatin cells. Calam, J. European journal of gastroenterology & hepatology. (1998) [Pubmed]
  25. Noncanonical DNA elements in the lamin B2 origin of DNA replication. Kusic, J., Kojic, S., Divac, A., Stefanovic, D. J. Biol. Chem. (2005) [Pubmed]
  26. Therapy of malignant intracranial hypertension by controlled lumbar cerebrospinal fluid drainage. Münch, E.C., Bauhuf, C., Horn, P., Roth, H.R., Schmiedek, P., Vajkoczy, P. Crit. Care Med. (2001) [Pubmed]
  27. A concise route to (+)-lactacystin. Ooi, H., Ishibashi, N., Iwabuchi, Y., Ishihara, J., Hatakeyama, S. J. Org. Chem. (2004) [Pubmed]
  28. Measurement of insulin-like growth factor II by a specific radioreceptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor-associated hypoglycemia. Daughaday, W.H., Trivedi, B., Kapadia, M. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  29. Clinical pharmacokinetics of ketorolac tromethamine. Brocks, D.R., Jamali, F. Clinical pharmacokinetics. (1992) [Pubmed]
  30. Combined effects of buffer and adrenergic agents on postresuscitation myocardial function. Sun, S., Weil, M.H., Tang, W., Povoas, H.P., Mason, E. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  31. Treatment of cyclophosphamide-induced hemorrhagic cystitis with intravesical carboprost tromethamine. Levine, L.A., Jarrard, D.F. J. Urol. (1993) [Pubmed]
  32. Re: Tham et al.--Safety of ERCP during pregnancy. Savas, M.C., Kadayifci, A., Koruk, M. Am. J. Gastroenterol. (2003) [Pubmed]
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