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MeSH Review:

Polycystic Ovary Syndrome

Weil, S. et al., Valkov, I.M. et al., Rosenfeld, R.S. et al., Györy, G. et al., Paris, J. et al., et al.

Zhou, Bird, Dumesic, Abbott, Prata Lima, Baracat, Simões,

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Disease relevance of Polycystic Ovary Syndrome

Dehydroisoandrosterone (DHA) and cortisol were measured by radioimmunoassay and protein binding techniques respectively in plasma from blood taken at 20-min intervals over 24-h periods in 3 normal men, 2 women with Stein-Leventhal syndrome and a man with a benign adrenocortical adenoma [1].
This includes women with classic polycystic ovary syndrome (C-PCOS), those with ovulatory (OV) PCOS, and women with idiopathic hyperandrogenism (IHA), which occurs in women with normal ovaries [2].
Endometrial carcinoma in Stein-Leventhal syndrome treated with hydroxyprogesterone caproate [3].
It possesses a powerful antiandrogenic effect, which, in addition to the classic uses for progestogens, may make TX 066 useful in the treatment of certain diseases such as prostatic hypertrophy or the Stein-Leventhal syndrome [4].

High impact information on Polycystic Ovary Syndrome

Finally, VPF/VEGF was overexpressed in the hyperthecotic ovarian stroma of Stein-Leventhal syndrome in which it may also have a pathophysiological role [5].
CONTEXT: Adrenal androgen excess is found in approximately 25-60% of women with polycystic ovary syndrome (PCOS), but the mechanisms underlying PCOS-related adrenal androgen excess are unclear [6].
The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome [7].
Women with polycystic ovary syndrome have significantly higher rates of pregnancy loss, as well as elevated insulin and IGF-1 levels [8].
Both before and after operation patients with the Stein-Leventhal syndrome had low plasma oestradiol levels [9].

Chemical compound and disease context of Polycystic Ovary Syndrome

Valproic acid fails to induce polycystic ovary syndrome in female rats [10].
The delta4/3betaOH ratio reflecting 3beta-hydroxysteroid dehydrogenase activity was decreased only in same patients with the Stein-Leventhal syndrome suggesting that the impaired function of this enzyme is not an obligatory feature of polycystic ovaries [11].
Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome [12].

Anatomical context of Polycystic Ovary Syndrome

OBJECTIVE: To investigate the effects of testosterone on cancellous bone and marrow adipocytes in a young female rat model of polycystic ovary syndrome (PCOS) [13].

Gene context of Polycystic Ovary Syndrome

Effect of ovarian wedge resection for the Stein-Leventhal syndrome on plasma FSH, LH, oestradiol and testosterone levels and on the responses of the pituitary to intravenous LHRH [9].

References

24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate. Rosenfeld, R.S., Rosenberg, B.J., Fukushima, D.K., Hellman, L. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters. Carmina, E., Chu, M.C., Longo, R.A., Rini, G.B., Lobo, R.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
Endometrial carcinoma in Stein-Leventhal syndrome treated with hydroxyprogesterone caproate. Eddy, W.A. Am. J. Obstet. Gynecol. (1978) [Pubmed]
The pharmacological profile of TX 066 (17 alpha-acetoxy-6-methyl-19-nor-4,6-pregna-diene-3,20-dione), a new oral progestative. Paris, J., Thévenot, R., Bonnet, P., Granero, M. Arzneimittel-Forschung. (1983) [Pubmed]
Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development. Kamat, B.R., Brown, L.F., Manseau, E.J., Senger, D.R., Dvorak, H.F. Am. J. Pathol. (1995) [Pubmed]
Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. Zhou, R., Bird, I.M., Dumesic, D.A., Abbott, D.H. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development. Weil, S., Vendola, K., Zhou, J., Bondy, C.A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Chi, M.M., Schlein, A.L., Moley, K.H. Endocrinology (2000) [Pubmed]
Effect of ovarian wedge resection for the Stein-Leventhal syndrome on plasma FSH, LH, oestradiol and testosterone levels and on the responses of the pituitary to intravenous LHRH. Valkov, I.M., Dokumov, S.I. British journal of obstetrics and gynaecology. (1977) [Pubmed]
Valproic acid fails to induce polycystic ovary syndrome in female rats. Lagace, D.C., Nachtigal, M.W. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries. Györy, G., Kiss, C., Fehér, T., Poteczin, E. Endokrinologie. (1975) [Pubmed]
Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome. Prata Lima, M.F., Baracat, E.C., Simões, M.J. Braz. J. Med. Biol. Res. (2004) [Pubmed]
Effects of testosterone on cancellous bone, marrow adipocytes, and ovarian phenotype in a young female rat model of polycystic ovary syndrome. Tamura, N., Kurabayashi, T., Nagata, H., Matsushita, H., Yahata, T., Tanaka, K. Fertil. Steril. (2005) [Pubmed]

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