Disease relevance of Pulmonary Blastoma

• To elucidate the contribution of beta-catenin gene mutation to the development of pulmonary blastomas, we analysed mutations in three well-differentiated fetal adenocarcinomas (WDFAs) and six biphasic pulmonary blastomas (BPBs) [1].
• Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma [2].

High impact information on Pulmonary Blastoma

• Beta-catenin mutations in pulmonary blastomas: association with morule formation [1].
• Furthermore, the finding of a small percentage of p53-positive tumor cells within one or both components suggests late acquisition of p53 mutational change in a subset of pulmonary blastomas [3].
• We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor [4].
• We report two cases of pulmonary blastoma with rhabdomyoblastic differentiation documented for the first time by electron microscopy and immunohistochemistry including documentation for myoglobin, actin, vimentin and desmin [5].
• The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis [6].

Chemical compound and disease context of Pulmonary Blastoma

• A case of a 7-year-old girl with pulmonary blastoma is reported in which the primary tumor is extremely Ga-67-avid and in which the gallium scans were helpful in determining early recurrence and metastatic disease to the brain [7].
• We report a case of biphasic pulmonary blastoma in an adult male who underwent liver transplant for hepatocellular carcinoma in March 1999, followed by immunosuppressive treatment and adjuvant chemotherapy with epirubicin [8].

Gene context of Pulmonary Blastoma

• In five of 10 carcinosarcomas and in one of three pulmonary blastomas, accumulation of the p53 epitopes Pab 1801 and/or DO-1 was found [9].
• Three cases of pulmonary blastoma (PB) were investigated microscopically with conventional stainings and immunohistochemically with monoclonal antibodies to cytokeratin, vimentin, desmin and neurofilament protein [10].
• Thyroid transcription factor-1 expression in pulmonary blastoma [11].
• Radiological case of the month. Congenital cystic adenomatoid malformation of the lung and pulmonary blastoma [12].
• Expression of KIT (CD117) in biphasic pulmonary blastoma. Novel data on histogenesis [13].

References