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MeSH Review

Nevus, Blue

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Disease relevance of Nevus, Blue

  • A strong cytoplasmic MIF positivity was found in most samples, although it was more heterogeneous in malignant tumours; MIF nuclear expression characterized Spitz/blue nevi, atypical nevi, melanomas and metastases [1].
  • Tissue samples of 55 formalin-fixed, paraffin-embedded melanoma (primary n=32, metastatic n=23) and of 27 control cases (junctional dermal, compound, Spitz, Reed, blue nevi, balloon-cell nevus, lentigo maligna) were analyzed by immunohistochemistry with anti-cellular apoptosis susceptibility antibodies [2].

High impact information on Nevus, Blue


Anatomical context of Nevus, Blue


Gene context of Nevus, Blue


  1. Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours. Miracco, C., De Nisi, M.C., Arcuri, F., Cosci, E., Pacenti, L., Toscano, M., Lalinga, A.V., Biagioli, M., Rubegni, P., Vatti, R., Maellaro, E., Del Bello, B., Massi, D., Luzi, P., Tosi, P. Int. J. Oncol. (2006) [Pubmed]
  2. Expression of the proliferation and apoptosis-associated CAS protein in benign and malignant cutaneous melanocytic lesions. Böni, R., Wellmann, A., Man, Y.G., Hofbauer, G., Brinkmann, U. The American Journal of dermatopathology. (1999) [Pubmed]
  3. Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. Shapiro, R.L., Duquette, J.G., Roses, D.F., Nunes, I., Harris, M.N., Kamino, H., Wilson, E.L., Rifkin, D.B. Cancer Res. (1996) [Pubmed]
  4. Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin. van den Oord, J.J., Paemen, L., Opdenakker, G., de Wolf-Peeters, C. Am. J. Pathol. (1997) [Pubmed]
  5. Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus. Zembowicz, A., Carney, J.A., Mihm, M.C. Am. J. Surg. Pathol. (2004) [Pubmed]
  6. Blue nevus of the uterine cervix. Patel, D.S., Bhagavan, B.S. Hum. Pathol. (1985) [Pubmed]
  7. Nonmelanized macromelanosomes in a cellular blue nevus. Light and electron microscopic observations. Tschen, J.A., Cartwright, J., Font, R.L. Archives of dermatology. (1989) [Pubmed]
  8. Congenital giant melanocytic nevus with pigmented epithelioid cells: a variant of epithelioid blue nevus. Martínez-Barba, E., Polo-García, L.A., Ferri-Níguez, B., Ruiz-Maciá, J.A., Kutzner, H., Requena, L. The American Journal of dermatopathology. (2002) [Pubmed]
  9. met and HGF-SF in normal melanocytes and melanoma cells. Halaban, R., Rubin, J.S., White, W. EXS. (1993) [Pubmed]
  10. S-100 protein content of dermal and oral mucosal blue nevi. Lovas, G., Wysocki, G., Daley, T., Rowden, G. J. Oral Pathol. (1986) [Pubmed]
  11. CD34-positive cellular blue nevi. Smith, K., Germain, M., Williams, J., Skelton, H. J. Cutan. Pathol. (2001) [Pubmed]
  12. Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. Kucher, C., Zhang, P.J., Pasha, T., Elenitsas, R., Wu, H., Ming, M.E., Elder, D.E., Xu, X. The American Journal of dermatopathology. (2004) [Pubmed]
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