Disease relevance of Nevus, Blue

• A strong cytoplasmic MIF positivity was found in most samples, although it was more heterogeneous in malignant tumours; MIF nuclear expression characterized Spitz/blue nevi, atypical nevi, melanomas and metastases [1].
• Tissue samples of 55 formalin-fixed, paraffin-embedded melanoma (primary n=32, metastatic n=23) and of 27 control cases (junctional dermal, compound, Spitz, Reed, blue nevi, balloon-cell nevus, lentigo maligna) were analyzed by immunohistochemistry with anti-cellular apoptosis susceptibility antibodies [2].

High impact information on Nevus, Blue

• Cellular blue nevi were induced in 100% of uPA-/- and uPA+/+ promoted animals [3].
• In benign pigment cell lesions, EMMPRIN but not gelatinase B was expressed in cellular blue nevi whereas all other benign lesions, including common blue nevi, were negative [4].
• Ulceration was the only feature more common in PEM than epithelioid blue nevi of Carney complex [5].
• Immunocytochemical studies for the localization of S-100 protein in the blue nevus cells were performed [6].
• Nonmelanized macromelanosomes in a cellular blue nevus. Light and electron microscopic observations [7].

Anatomical context of Nevus, Blue

• Epithelioid-cell blue nevus is an unusual cytologic variant of blue nevus that has been recently described mostly in patients with Carney complex, although the lesion may also appear in patients with no evidence of Carney complex [8].
• Melanocytes from a recurrent blue nevus were also stimulated by HGF-SF, whereas cells from advanced primary and metastatic lesions either did not respond, were only slightly stimulated or, in one case, were inhibited [9].
• Three common blue nevi from skin of the trunk and upper extremities, and 5 from oral mucosae were studied using an immunoperoxidase stain for S-100 protein [10].

Gene context of Nevus, Blue

• CD34-positive cellular blue nevi [11].
• CONCLUSION: The sclerotic/desmoplastic and hypopigmented blue nevi were uniformly positive for Melan-A, while the vast majority of DMM were negative in their spindle cell compartments [12].

References