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Disease relevance of Lentigo


High impact information on Lentigo


Chemical compound and disease context of Lentigo

  • Azelaic acid was successfully used in the clinical treatment of 7 cases of lentigo maligna in that remission of the lesions was observed in all our patients [10].
  • Several reports have been published over the last two decades describing the successful removal of benign cutaneous pigmented lesions such as lentigines, café au lait macules' nevi, nevus of Ota, and lentigo maligna by a variety of lasers such as the excimer (351 nm), argon (488,514 nm), ruby (694 nm), Nd:YAG (1060 nm), and CO2 (10,600 nm) [11].
  • Treatment of lentigo maligna with tazarotene 0.1% gel [12].
  • Oestrogen and progesterone receptors in lentigo maligna [13].
  • No effect of topical tretinoin on lentigo maligna [14].

Biological context of Lentigo


Anatomical context of Lentigo


Gene context of Lentigo


Analytical, diagnostic and therapeutic context of Lentigo


  1. Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. Stratakis, C.A., Carney, J.A., Lin, J.P., Papanicolaou, D.A., Karl, M., Kastner, D.L., Pras, E., Chrousos, G.P. J. Clin. Invest. (1996) [Pubmed]
  2. Cyclin D1 is a candidate oncogene in cutaneous melanoma. Sauter, E.R., Yeo, U.C., von Stemm, A., Zhu, W., Litwin, S., Tichansky, D.S., Pistritto, G., Nesbit, M., Pinkel, D., Herlyn, M., Bastian, B.C. Cancer Res. (2002) [Pubmed]
  3. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. Stratakis, C.A., Kirschner, L.S., Carney, J.A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  4. Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex). Pack, S.D., Kirschner, L.S., Pak, E., Zhuang, Z., Carney, J.A., Stratakis, C.A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  5. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. Kadono, S., Manaka, I., Kawashima, M., Kobayashi, T., Imokawa, G. J. Invest. Dermatol. (2001) [Pubmed]
  6. Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum. Spatz, A., Giglia-Mari, G., Benhamou, S., Sarasin, A. Cancer Res. (2001) [Pubmed]
  7. Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin. van den Oord, J.J., Paemen, L., Opdenakker, G., de Wolf-Peeters, C. Am. J. Pathol. (1997) [Pubmed]
  8. Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy. Stratakis, C.A., Papageorgiou, T., Premkumar, A., Pack, S., Kirschner, L.S., Taymans, S.E., Zhuang, Z., Oelkers, W.H., Carney, J.A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  9. Prevalence of exon 15 BRAF mutations in primary melanoma of the superficial spreading, nodular, acral, and lentigo maligna subtypes. Lang, J., MacKie, R.M. J. Invest. Dermatol. (2005) [Pubmed]
  10. Inhibition of DNA synthesis of melanoma cells by azelaic acid. Leibl, H., Stingl, G., Pehamberger, H., Korschan, H., Konrad, K., Wolff, K. J. Invest. Dermatol. (1985) [Pubmed]
  11. Effect of wavelength on cutaneous pigment using pulsed irradiation. Sherwood, K.A., Murray, S., Kurban, A.K., Tan, O.T. J. Invest. Dermatol. (1989) [Pubmed]
  12. Treatment of lentigo maligna with tazarotene 0.1% gel. Chimenti, S., Carrozzo, A.M., Citarella, L., De Felice, C., Peris, K. J. Am. Acad. Dermatol. (2004) [Pubmed]
  13. Oestrogen and progesterone receptors in lentigo maligna. Sawaya, M.E., Garland, L.D., Rothe, M.J., Honig, L.S., Hsia, S.L. Br. J. Dermatol. (1988) [Pubmed]
  14. No effect of topical tretinoin on lentigo maligna. Rivers, J.K., McCarthy, W.H. Archives of dermatology. (1991) [Pubmed]
  15. Genetics of Peutz-Jeghers syndrome, Carney complex and other familial lentiginoses. Stratakis, C.A. Horm. Res. (2000) [Pubmed]
  16. Lentiginosis profusa syndrome. IV. Giant pigment granules (light microscopy). Selmanowitz, V.J. Acta Derm. Venereol. (1975) [Pubmed]
  17. Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex). Stratakis, C.A., Courcoutsakis, N.A., Abati, A., Filie, A., Doppman, J.L., Carney, J.A., Shawker, T. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  18. Differential expression of proliferation- and apoptosis-related markers in lentigo maligna and solar keratosis keratinocytes. Feinmesser, M., Tsabari, C., Fichman, S., Hodak, E., Sulkes, J., Okon, E. The American Journal of dermatopathology. (2003) [Pubmed]
  19. Hypertrophic cardiomyopathy in combination with juvenile amaurotic idiocy. Chance or fundamentally related findings? Baandrup, U., Rosenskjold, B., Bjerregaard, P. British heart journal. (1984) [Pubmed]
  20. Relationship between DNA ploidy-related parameters and the deletions in mismatch repair genes MLH1 and MSH2 in lentigo maligna and malignant melanomas. Korabiowska, M., Viehöver, M., Schlott, T., Berger, H., Droese, M., Brinck, U. Arch. Dermatol. Res. (2001) [Pubmed]
  21. Chromosome 2 (2p16) abnormalities in Carney complex tumours. Matyakhina, L., Pack, S., Kirschner, L.S., Pak, E., Mannan, P., Jaikumar, J., Taymans, S.E., Sandrini, F., Carney, J.A., Stratakis, C.A. J. Med. Genet. (2003) [Pubmed]
  22. Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype. Ibrahim, e.l. .C., Aractingi, S., Allory, Y., Borrini, F., Dupuy, A., Duvillard, P., Carosella, E.D., Avril, M.F., Paul, P. Int. J. Cancer (2004) [Pubmed]
  23. Immunohistochemical staining of lentigo maligna during Mohs micrographic surgery using MART-1. Kelley, L.C., Starkus, L. J. Am. Acad. Dermatol. (2002) [Pubmed]
  24. Carney complex and the familial lentiginosis syndromes: link to inherited neoplasias and developmental disorders, and genetic loci. Chrousos, G.P., Stratakis, C.A. J. Intern. Med. (1998) [Pubmed]
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