Disease relevance of Schizophrenia, Catatonic

• Fever, tachycardia, and hypertension developed concurrently with the administration of thiothixene during an acute episode of agitation in a case of catatonic schizophrenia [1].

Psychiatry related information on Schizophrenia, Catatonic

• 2. This region was suggested to be involved in the etiopathogenesis of: (a) schizophrenia combined with a neurophysiological deficit; (b) lithium-responsive bipolar disorder; and (c) familial catatonic schizophrenia (periodic catatonia) [2].

High impact information on Schizophrenia, Catatonic

• Memantine and catatonic schizophrenia [3].
• This result provides strong evidence that a gene located telomeric to CHRNA7 is causative for the pathogenesis of catatonic schizophrenia in this family [2].
• Association of WKL1/MLC1 with catatonic schizophrenia [4].
• Clonazepam for the treatment of stupor in catatonic schizophrenia [5].
• Lorazepam: therapeutic for catatonic schizophrenia [6]?

Chemical compound and disease context of Schizophrenia, Catatonic

• Recessive mutations within human MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), whereas a missense mutation resulting in a methionine substitution within a transmembrane leucine string of MLC has been implicated in catatonic schizophrenia in a large pedigree [7].
• This case report documents the response of a young, first-episode, neuroleptic naive male with severe catatonic schizophrenia to the novel antipsychotic, risperidone [8].
• Response of catatonic schizophrenia to amisulpride: a case report [9].
• While its mechanism of action is unknown, it has been thought that glutamate antagonists, such as memantine, may be beneficial in catatonic schizophrenia due to a glutamatergic dysfunction present in catatonic patients [10].
• Acute dystonia induced by adding midodrine, a selective alpha 1 agonist, to risperidone in a patient with catatonic schizophrenia [11].

Biological context of Schizophrenia, Catatonic

• No variant exclusively cosegregates with the disease in a large pedigree that mainly supports the chromosome 15q14 locus, providing evidence that CX36 is not causative for the pathogenesis of catatonic schizophrenia in this family [12].

Gene context of Schizophrenia, Catatonic

• Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia [7].
• The role, suggested by others, of a mutation in the MLC1gene in catatonic schizophrenia and the possible function of the MLC1 protein as a cation channel are discussed [13].
• Mutational analysis of the connexin 36 gene (CX36) and exclusion of the coding sequence as a candidate region for catatonic schizophrenia in a large pedigree [12].
• No variant exclusively co-segregates with the disease in the large pedigree, providing evidence that CELSR1 is not causative for the pathogenesis of catatonic schizophrenia in this family [14].
• Myelin basic protein antibodies in catatonic schizophrenia [15].

References