Disease relevance of Navane

• Leukopenia following treatment with thiothixene and haloperidol [1].
• The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range [2].
• Motility, Parkinsonism, and prolactin with thiothixene and thioridazine [3].
• Fever, tachycardia, and hypertension developed concurrently with the administration of thiothixene during an acute episode of agitation in a case of catatonic schizophrenia [4].
• Exaggerated hyperprolactinemia in response to thiothixene [5].

Psychiatry related information on Navane

• Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo [6].
• A high incidence of akathisia in the thiothixene group was responsible for a statistically significant difference between groups in the number of central nervous system symptoms [7].
• In thiothixene group significant improvement was noticed on all the target symptoms except 'tension' and 'depressive mood'. The ethnic or genetic make up of the patient population was concluded to be the reason for non-effectiveness of thisthixene on effective psychopathology in acute schizophrenia [8].
• Response to thiothixene has been found to be related to the patient's Minnesota Multiphasic Personality Inventory (MMPI) profile prior to treatment [9].
• Proceedings: A comparative study of thiothixene and chlorpromazine in chronic schizophrenic patients: application of a special psychometric test battery [10].

High impact information on Navane

• Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week [2].
• A random sample of 52 borderline and schizotypal patients was treated with two major neuroleptics, thiothixene and haloperidol, in a double-blind study [11].
• Thirty-six hospitalized patients with schizophrenia or schizo-affective disorder who were judged unresponsive to conventional treatment were tested 5 days after last receiving medication and retested 4 weeks after treatment with thiothixene, loxapine, or molindone [12].
• Clozapine increased and thiothixene decreased metabolic rates in the basal ganglia; these effects were most marked on the right side [13].
• Patients had a second PET scan after an injection of thiothixene to evaluate the effects of acute neuroleptics on glucose metabolism [14].

Chemical compound and disease context of Navane

• Thrombocytopenia associated with chlorpromazine, haloperidol and thiothixene: a case report [15].
• Progressive supranuclear palsy with agitation: response to trazodone but not to thiothixine or carbamazepine [16].
• Perphenazine was discontinued after the fourth episode of priapism and antipsychotic treatment with thiothixene was subsequently initiated [17].
• Penfluridol and thiothixene. Dosage, plasma levels and changes in psychopathology [18].

Biological context of Navane

• By that time plasma levels of thiothixene had decreased to about 30 per cent of the initial value, indicating strong enzyme induction [19].
• The effect of paroxetine on thiothixene pharmacokinetics [20].
• There was also a tendency towards a lower stroke volume after this drug and thiothixene during exercise [21].

Anatomical context of Navane

• Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene [22].
• The problem of accurate determination of tiotixene in body fluids is still challenging [23].

Associations of Navane with other chemical compounds

• The mean daily dosage of thiothixene hydrochloride in the final week of the study was 8.7 mg, a lower dosage than is used in outpatient schizophrenics [6].
• A 41-year-old female ingested 4.5 g venlafaxine, 500 mg diphenhydramine, 50 mg thiothixene and subsequently experienced severe central nervous system depression requiring intubation [24].
• Among the evaluated compounds, chlorpromazine, phenoxazine, ethylpropazine, 9-oxo-9H-thioxanthene-3-carbonitrile-10,10-dioxide, thiothixene and phenothiazine showed profound inhibition of EBV-EA in the in vitro assay [25].
• We discuss fluotracen in relation to other neuroleptics and thymoleptics, and we suggest that comparative studies with thiothixene might be informative [26].

Gene context of Navane

• DISCUSSION: It is likely that the CYP2D6 isoenzyme is not responsible for a high proportion of thiothixene clearance, but one cannot exclude the possibility that a longer paroxetine pretreatment might have caused some inhibition of thiothixene clearance [20].
• Effect of melperone, two of its metabolites and thiothixene on central monoamine metabolism and prolactin levels in rodents [27].

Analytical, diagnostic and therapeutic context of Navane

• Twelve patients with schizophrenia received positron emission tomography scans with 18F-deoxyglucose before and after 4 to 6 weeks of treatment with clozapine or thiothixene [13].
• 8-Chloro-5-methoxy-2-morpholinomethyl-1-tetralone exhibits neuroleptic potency in the thiothixene range in animal models [28].
• Fifty-nine plasma thiothixene concentrations were measured in 42 patients as part of routine therapeutic drug monitoring [29].
• Plasma levels of thiothixene by radioreceptor assay: clinical usefulness [30].
• Quantitation of thiothixene in plasma by high-performance thin-layer chromatography and fluorometric detection [31].

References