Disease relevance of Heart Murmurs

• Thirteen small breed dogs with heart murmurs due to mitral regurgitation of varying severity received medetomidine as a sedative drug for teeth cleaning procedures [1].
• METHODS: One hundred and fifty-two children with congenital heart defects (patients), and an equal number of children with innocent cardiac murmurs (controls) attending the Pediatric Cardiology Outpatient Clinic at Sultan Qaboos University Hospital, Muscat, Oman from 1997 to 1998 were prospectively studied [2].
• The first was a 13-month-old boy with tuberous sclerosis and multiple rhabdomyomas of the heart, who presented with a postpartal cardiac murmur and moderate cardiomegaly [3].
• In this prospective echocardiographic study, we investigated the occurrence of mitral valve prolapse (MVP) in 60 dachshunds: 30 with mitral regurgitation (MR), 15 age-matched and 15 3-year-old controls without heart murmurs [4].

High impact information on Heart Murmurs

• Other factors associated with death included age (by decade; HR, 1.20), heart rate (by decile; HR, 1.13), urea nitrogen level (by decile; HR, 1.20), systolic blood pressure less than 100 mm Hg (HR, 1.94), heart murmur (HR, 1.92), and New York Heart Association classification (HR, 1.38 for each increase in class) [5].
• Children with heart murmurs: can ventricular septal defect be diagnosed reliably without an echocardiogram [6]?
• New heart murmur and fever in a patient with systemic lupus erythematosus [7].
• Heart murmurs heard in 31 dexfenfluramine users (14%) and in 20 controls (11%) were all systolic and of grade I to II/VI intensity [8].
• The severity of MVP was mild; nearly all of the cases were silent, without cardiac murmur, and there was no problem with the left ventricular function [9].

Chemical compound and disease context of Heart Murmurs

• We describe a woman with seropositive, erosive rheumatoid arthritis who, on two occasions, developed nonperiarticular subcutaneous nodules and new heart murmurs during methotrexate therapy, while her arthritis remained under good control [10].
• A systolic heart murmur was auscultated in a 2-yr-old female Sumatran orangutan (Pongo pygmaeus sumatraensis) with a slower than expected growth rate [11].

Gene context of Heart Murmurs

• Time-frequency analysis of heart murmurs. Part I: Parametric modelling and numerical simulations [12].
• Fifty consecutive patients (36 male, 14 female, mean age 28 years) who had heart murmurs and clinical and radiographic evidence of straight upper dorsal spine (straight back syndrome, SBS) underwent detailed clinical, electrocardiographic, roentgenographic, and echocardiographic evaluation [13].
• We concluded that the absence of a flap sign (valve-like openings of the defects) affects the development of the heart murmur of ASD found in the neonatal period [14].
• The classic diagnostic triad of fever, cardiac murmur, and positive blood cultures are not always present [15].
• Clinicians should maintain a high index of suspicion for dilated cardiomyopathy in any patient with cardiac murmur and systematic symptoms [16].

Analytical, diagnostic and therapeutic context of Heart Murmurs

• In a control group of 40 age- and sex-matched patients (26 male, 14 female, mean age 29.5 years), who also had heart murmurs but lacked straight upper dorsal spine, only 7 (17.5%) had MVP and none had BAV [13].

References