Disease relevance of Akinetic Mutism

• Decrease in consciousness occurred with resultant coma, focal and generalized seizures and the occasional appearance of a state of akinetic mutism [1].
• Coma, vegetative state, lock-in syndrome and akinetic mutism are defined [2].

Psychiatry related information on Akinetic Mutism

• The 19 patients with paramedian thalamopeduncular infarcts had marked disturbances of consciousness (hypersomnia, deep coma, akinetic mutism) associated with ocular motility changes [3].

High impact information on Akinetic Mutism

• Akinetic mutism after baclofen [4].
• Akinetic mutism from hypothalamic damage: successful treatment with dopamine agonists [5].
• In these patients the time course of the akinetic mutism and extrapyramidal syndrome, which developed in the absence of any other identifiable cause, suggests cyclosporin A was the precipitating factor [6].
• By revealing a high level of cognitive integration of environmental auditory information, our study emphasizes the potential clinical relevance of MMN and P300 recordings in akinetic mutism to assess patient cognitive functioning [7].
• Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase [8].

Chemical compound and disease context of Akinetic Mutism

• The girl had spontaneous relief of her akinetic mutism 1 month later, after parenteral antibiotics and multiple shunt revisions [9].
• Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism [10].
• A parkinsonian extrapyramidal syndrome, complicating organophosphate intoxication, should therefore also be taken into account in any patient with organophosphate poisoning, presenting with marked behavioural alterations, rigidity or akinetic mutism, and beneficial response to amantadine [11].
• Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning [12].

Gene context of Akinetic Mutism

• A parkinsonian extrapyramidal syndrome complicating SLE should therefore be taken into account in any patient with SLE presenting with marked behavioral alterations, rigidity, or akinetic mutism [13].
• The value of MBP and CCT improved with recovery from akinetic mutism [14].

References