Disease relevance of Precipitating Factors

• Reduced expression of the LDLR is believed to be a precipitating factor in the pathogenesis of type III hyperlipoproteinemia (HLP) in some humans homozygous for the apoE2 allele (APOE*2) [1].
• An important precipitating factor of clinically relevant arrhythmias is the introoperative use of epinephrine [2].
• In two patients with dilated thoracic aortas and aortic regurgitation, the attacks of paroxysmal hypertension occurred without apparent precipitating factors and were followed by anginal pain with marked ST depression [3].
• The implications of these results are discussed, especially with respect to observations which indicate that homocysteine may be a precipitating factor in the development of thrombosis [4].
• Reports of 39 patients who developed pulmonary toxicity with amiodarone were evaluated for clues to precipitating factors and information on the response to corticosteroid treatment [5].

Psychiatry related information on Precipitating Factors

• The only precipitating factor to be found was the chronic and unnecessary overuse of furosemide, apparently resulting from a psychological profile of anorexia nervosa [6].
• Most frequent precipitating factors pointed out by the patients were emotional stress, irritation by sweat or UV light and longstanding use of steroid ointment [7].
• Hyperventilation was the most common precipitating factor for CAE, and sleep deprivation was the most common one for JME and GMA [8].

High impact information on Precipitating Factors

• No precipitating factor other than methotrexate could be identified [9].
• Possible precipitating factors were identified in only five cases: intercurrent infection (one); discontinuation of lithium (one) and tetrabenazine (one); and the introduction of clonazepam (two) [10].
• Taken collectively, these results indicate that S. stercoralis infection induces polyclonal expansion of HTLV-1-infected cells by activating the IL-2/IL-2R system in dually infected carriers, an event which may be a precipitating factor for ATL and inflammatory diseases [11].
• Cocaine users were less likely than controls to have an intercurrent illness identified as a precipitating factor for DKA (14.7% vs 33.1%; P<.001) and were more likely to have missed taking insulin prior to admission (45.1% vs 24.7%; P<.001) [12].
• Biochemical diagnosis is problematic and the identification of mutations in the HMB-synthase gene provides accurate detection of presymptomatic heterozygotes, permitting avoidance of the acute precipitating factors [13].

Chemical compound and disease context of Precipitating Factors

• This case illustrates that reversible impairment of renal function and hyperkalemia can present after 2 years of treatment with angiotensin-converting enzyme inhibitors in patients with precipitating factors [14].
• Twenty patients had one or more identifiable precipitating factors, including warfarin administration (4), angiography (15), angioplasty (2), intra-aortic balloon pump placement (2), vascular surgery (11), aortitis (2), and cardiopulmonary resuscitation (1) [15].
• We concluded that in our patient acute renal insufficiency aggravated by diclofenac treatment probably associated with an inadvertent withdrawal could have been the precipitating factor for transient protein C deficiency [16].
• Benzodiazepine-like compounds (BZDs), either taken with the diet or synthesized by intestinal bacterial flora, may represent a precipitating factor for hepatic encephalopathy (HE) in cirrhotic patients [17].
• We could not recognize any other precipitating factor beyond the infusion of gemcitabine as a cause for the arrhythmia [18].

Biological context of Precipitating Factors

• The leukemic process may play some role in glucose homeostasis and may be considered as a precipitating factor for DKA [19].
• The crisis has an abrupt onset, and is evoked by a precipitating factor such as infectious diseases, ketoacidosis, acute trauma, thyroidal surgery, 131-I radio-metabolic treatment, administration of iodine-containing materials (amiodarone), parturition [20].

Anatomical context of Precipitating Factors

• We conclude that estrogen alone, in the absence of aging and other known precipitating factors for stress incontinence, is of minimal significance in maintaining normal urinary tract physiology [21].
• Therefore, the effects of impaired ornithine transport into mitochondria, which seemed to be a possible precipitating factor, were examined by numerical simulation of the urea cycle [22].
• CONCLUSIONS: We called this unrecognized potentially reversible late-onset worsening azotemia, occurring several months to years on stable AB, in CKD patients with normal renal arteries, without precipitating factors, late-onset renal failure from angiotensin blockade (LORFFAB) [23].
• Thyroid storm as precipitating factor in onset of coma in an elderly woman: case report and literature review [24].

Associations of Precipitating Factors with chemical compounds

• Evaluation of precipitating factors revealed that AS coincided with benzodiazepine withdrawal in eight cases [25].
• However, many patients responded well to haloperidol and to the discontinuation of oral contraceptives if this was the precipitating factor [26].
• DNA was extracted from formalin-fixed, paraffin-embedded specimens of cutaneous lesions of HAEM and also from EM for which no precipitating factor could be documented, otherwise known as idiopathic EM (IPEM) [27].
• Precipitating factors in spontaneous recurrence of methamphetamine psychosis [28].
• We propose that cyclosporine may have been an important precipitating factor of the neurological syndrome of these patients [29].

Gene context of Precipitating Factors

• CONCLUSIONS: CYP1A1 4887A may be a precipitating factor for the development of SLE [30].
• Trends in the mortality rates, morbidity rates, and hematologic screening parameters for hemochromatosis in the United States over the past 20 years were examined to assess whether dietary iron supplementation is a precipitating factor for hemochromatosis [31].
• In this study, we quantified the bronchial wall thickness and evaluated HRCT features in 57 BA subjects (338 bronchi) who had precipitating factors of irreversible airway remodeling, 19 COPD subjects (70 bronchi) and 10 healthy subjects (23 bronchi) [32].
• Furthermore, studies using mice deficient in tPA has demonstrated that tPA is important for the stress reaction, a common precipitating factor for MDD [33].
• This suggests that in addition to G-CSF, the presence of precipitating factors that can synergistically enhance or accelerate the outbreak of the disease is required for the development of bullous lesions [34].

References